Gentime

Description

Gentime Cream: Uses, Dosage, & Important Information

Gentime Cream, containing Gentamicin Topical (0.2% W/W), is an antibiotic cream used to treat various bacterial skin infections. It’s manufactured by Time Pharmaceuticals Pvt. Ltd. and is available in Nepal.

What is Gentime Cream Used For?

Gentime Cream is used to treat:

• Bacterial skin infections
• Burns
• Eczema
• Seborrheic dermatitis
• Ecthyma (a type of skin infection)
• Excoriation (skin picking)
• Folliculitis (inflamed hair follicles)
• Furunculosis (boils)
• Infected insect bites and stings
• Lacerations and abrasions (cuts and scrapes)
• Paronychia (nail fold infection)
• Pyoderma gangrenosum (a rare skin condition)
• Infected skin cysts and abscesses
• Stasis ulcers and other infected skin ulcers
• Bacterial, fungal, or viral superinfections (additional infections)
• Sycosis barbae (a chronic inflammation of beard follicles)
• Minor surgical wounds
• Infected contact dermatitis caused by susceptible organisms

How to Use Gentime Cream

Adult Dosage

Apply to the affected area 3-4 times daily.

Child Dosage

Children over 1 year: Apply to the affected area 3-4 times daily.

Renal Dose, Administration

Specific information for patients with kidney conditions or administration instructions beyond topical application are not provided. Always consult a healthcare professional for guidance, especially with specific medical conditions.

Important Considerations and Warnings

Do Not Use Gentime Cream If You Have:

• A history of hypersensitivity (allergy) to aminoglycoside antibiotics.
• Pregnancy.
• Hepatic impairment (liver problems).
• A skin rash (unless it’s the condition being treated).

Precautions:

• Concurrent use of neuromuscular blocking agents: Use with caution.
• Myasthenia gravis or Parkinsonism: Use with caution.
• Conditions predisposing to ototoxicity (ear damage) and nephrotoxicity (kidney damage): Use with caution.
• Lactation (breastfeeding): Gentamicin is excreted in breast milk, though no adverse effects on nursing infants have been reported. Use with caution and consult your doctor.
• Monitoring: Plasma concentrations of gentamicin should be monitored in patients receiving high doses or prolonged courses, as well as in infants, elderly patients, patients with renal impairment, cystic fibrosis, or significant obesity. Auditory (hearing) and renal (kidney) functions should also be monitored.

Interactions:

• Synergistic with: Ampicillin, benzylpenicillin, and other beta-lactam antibiotics (meaning they work better together).
• Increased risk of severe respiratory depression: When used concurrently with anesthetics or opioids.
• May reduce renal clearance of zalcitabine.
• May induce hypocalcemia (low calcium levels): When used with bisphosphonates.
• Not to be used with agalsidase alfa or beta: As it may inhibit alpha-galactosidase activity.
• Potentially Fatal Interactions:
  • Increased incidence of ototoxicity: When combined with ethacrynic acid and furosemide.
  • Potentiation of nephrotoxicity: Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone, and indomethacin can increase the risk of kidney damage.
  • Potentiates neuromuscular blocking agents: Can enhance their effects.

Possible Side Effects:

• Allergic contact dermatitis
• Erythema (redness)
• Pruritus (itching)

How Gentime Cream Works (Mechanism of Action)

Gentamicin is an aminoglycoside antibiotic. It works by binding to the 30s and 50s ribosomal subunits of susceptible bacteria. This action disrupts protein synthesis, making the bacterial cell membrane defective and ultimately killing the bacteria.

Disclaimer: This information is for general knowledge only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or another qualified healthcare provider with any questions about a medical condition or before starting any new treatment.