Emez 20

Description

Emez 20 Tablet: Your Guide to Acid Reflux Relief

Emez 20 Tablet is a medication used to treat various conditions related to excess stomach acid. It contains Esomeprazole Magnesium Trihydrate BP 20mg, a proton pump inhibitor (PPI) that works by reducing the amount of acid your stomach produces.

Manufactured by: Alive Pharmaceutical. Pvt. Ltd. Pack Size: 100 tablets Retail Price: 5.00 NPR Also Available As: 40mg Tablet

What is Emez 20 Tablet Used For?

Emez 20 Tablet is prescribed for a range of conditions, including:

• Heartburn and Acid-Related Dyspepsia (indigestion)
• Gastroesophageal Reflux Disease (GERD): A chronic condition where stomach acid flows back into the esophagus, causing irritation.
• Erosive Esophagitis: Damage to the esophagus caused by stomach acid.
• Peptic Ulcer Disease: Sores that develop on the lining of the stomach, small intestine, or esophagus.
• Zollinger-Ellison Syndrome: A rare condition causing the stomach to produce too much acid.
• Helicobacter pylori Infection: Used in combination with antibiotics to treat this bacterial infection that can cause ulcers.
• NSAID-Induced Gastric Ulcer: Ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs).
• Gouty Arthritis (Note: While listed, PPIs are generally not a primary treatment for gout itself but may be used to manage stomach issues from other gout medications).
• Duodenal and Gastric Ulcer

Dosage Information

Always follow your doctor’s instructions carefully when taking Emez 20 Tablet. Here are general dosage guidelines:

Adult Dosage

• GERD Without Erosive Esophagitis: Typically 20 mg once daily for 4 weeks. Your doctor might recommend another 4 weeks if symptoms persist.
• GERD With Erosive Esophagitis: Usually 20-40 mg once daily for 4-8 weeks.
• If Oral Medication Isn’t Possible: Your doctor might prescribe an intravenous (IV) dose of 20-40 mg daily for up to 10 days, switching to oral medication when you’re able to swallow.
• Maintenance for GERD: 20 mg once daily for up to 6 months.
• Reducing Risk of NSAID-Associated Gastric Ulcer: 20-40 mg once daily for up to 6 months.
• NSAID-Induced Gastric Ulcer Treatment: 20 mg once daily for 4-8 weeks.
• Zollinger-Ellison Syndrome: Initial dose of 80 mg, divided into two doses per day. Your doctor will adjust the dose based on your needs, up to a maximum of 240 mg per day.
• Elderly Patients: No dosage adjustment is typically needed.

Dosage for Children

• GERD Without Erosive Esophagitis (Oral):
  • Under 1 year: Not established.
  • 1-12 years: 10-20 mg once daily for up to 8 weeks.
  • Over 12 years: 20-40 mg once daily for up to 8 weeks.
• GERD With Erosive Esophagitis (Healing):
  • Under 1 month: Not established.
  • 1 month to 1 year:
    • 3.5 kg: 2.5 mg once daily for up to 6 weeks.

    • 3.5-7.5 kg: 5 mg once daily for up to 6 weeks.

    • 7.5 kg: 10 mg once daily for up to 6 weeks.

  • 1-12 years:
    • <20 kg: 10 mg once daily for 8 weeks.

    • 20 kg: 10-20 mg once daily for 8 weeks.

  • Over 12 years: 20-40 mg once daily for 4-8 weeks.
  • Maintenance: 20 mg once daily for up to 6 months.

Special Considerations

• Hepatic (Liver) Impairment:
  • Mild to Moderate (Child-Pugh A/B): No dosage adjustment.
  • Severe (Child-Pugh C): Do not exceed 20 mg per day.
• Renal (Kidney) Impairment: No dosage adjustment is typically needed.

How to Take Emez 20 Tablet

• Delayed-release capsules: Take on an empty stomach, ideally 1 hour before a meal.
• Tablets: Can be taken with or without food.

Important Warnings & Precautions

• Do not take Emez 20 Tablet if: You are allergic to esomeprazole, any of its ingredients, or other similar medications (substituted Benzimidazoles).
• Discuss with your doctor if you are:
  • Pregnant or breastfeeding.
  • Have liver problems (especially severe liver impairment – the dose should not exceed 20 mg).
  • Have or are at risk of certain infections, such as community-acquired pneumonia.
  • Have unexplained weight loss, vomiting, or difficulty swallowing, as these could be signs of a more serious underlying condition.
• Pregnancy and Breastfeeding: It’s unknown if esomeprazole passes into breast milk. Your doctor will weigh the benefits and risks if you are breastfeeding.

Potential Drug Interactions

Emez 20 Tablet can interact with other medications, potentially changing their effects. It’s crucial to tell your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies.

Be particularly aware of interactions with:

• Digoxin: May increase risk of heart-related side effects.
• Diuretics (water pills): Increased risk of low magnesium levels.
• Warfarin: May affect blood clotting time.
• Tacrolimus, Saquinavir, Methotrexate: May increase their levels in your body.
• Drugs metabolized by CYP2C19 (e.g., Diazepam): May interfere with their elimination.
• Ketoconazole, Erlotinib, Iron Salts: May decrease their absorption.
• Potentially Fatal Interactions:
  • May decrease the effectiveness of Rilpivirine, Atazanavir, and Nelfinavir (antiviral medications).
  • May decrease the antiplatelet effects of Clopidogrel (a blood thinner).

Possible Side Effects

Like all medications, Emez 20 Tablet can cause side effects, though not everyone experiences them.

Common Side Effects (>10%):

• Headache (2-11%)

Less Common Side Effects (1-10%):

• Bloating (flatulence), indigestion, nausea, abdominal pain, diarrhea, dry mouth, dizziness, constipation, drowsiness, itching.

Rare Side Effects (<1%):

• Serious blood disorders (agranulocytosis, pancytopenia), blurred vision, pancreatitis, inflamed mouth (stomatitis), microscopic colitis, liver failure, hepatitis (with or without jaundice), severe allergic reactions (anaphylactic reaction/shock), fungal infection in the gut (GI candidiasis), low magnesium levels (hypomagnesemia).
• Muscle weakness, muscle pain, bone fractures, liver encephalopathy, taste disturbances, aggression, agitation, depression, hallucinations, kidney inflammation (interstitial nephritis), male breast enlargement (gynecomastia), bronchospasm.
• Skin reactions like hair loss, severe skin rashes (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis – sometimes fatal), increased sweating, sensitivity to light.

How Emez 20 Tablet Works

Emez 20 is a Proton Pump Inhibitor (PPI). It works by specifically targeting and blocking the H+/K+ ATPase (often called the “proton pump”) in the acid-producing cells of your stomach. This action effectively suppresses the production of gastric acid, reducing acidity in your stomach and allowing conditions like ulcers and esophagitis to heal. Esomeprazole is the S-isomer of omeprazole, another well-known PPI.

Please Note: This information about Emez 20 Tablet is for general knowledge and should not be used for self-diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult with a qualified healthcare professional for any health concerns or before starting any new medication.