Diana Cream 0.025% Cream

Description

Diana Cream 0.025% Cream is a topical medication primarily used for various skin conditions, especially those related to cell turnover and pigmentation.

Active Ingredient and Classification:

• Active Ingredient: The primary active ingredient in Diana Cream 0.025% is Tretinoin, at a concentration of 0.025% w/w.
• Classification: Tretinoin is a retinoid, which is a derivative of Vitamin A. It is NOT a steroid cream. This is a crucial distinction, as steroids work differently (primarily by reducing inflammation) and have different side effect profiles, particularly with long-term use.

Uses of Diana Cream 0.025%: Diana Cream 0.025% (Tretinoin) is commonly prescribed for:

• Acne Vulgaris: It’s effective in treating various forms of acne, including spots, pimples, blackheads, and whiteheads, on the face, chest, or back. It works by reducing excessive oil production, promoting the shedding of dead skin cells, and preventing the formation of new comedones (clogged pores).
• Photodamaged Skin: It helps to improve the appearance of skin that has been damaged by sun exposure, including:
  • Fine wrinkles: Helps to reduce the appearance of fine lines.
  • Roughness: Smooths rough facial skin texture.
  • Mottled hyperpigmentation: Helps to fade dark spots and uneven skin tone caused by sun damage.

How it Works (Mechanism of Action): Tretinoin works by:

• Stimulating Cell Turnover: It increases the rate at which skin cells are replaced, helping to unclog pores and prevent new acne lesions from forming.
• Reducing Cohesiveness of Follicular Epithelial Cells: This facilitates the extrusion of existing comedones.
• Thinning the Stratum Corneum: This is the outermost layer of the skin, and thinning it can improve skin texture and appearance.

Side Effects: As a retinoid, Diana Cream can cause initial skin irritation as the skin adjusts. Common side effects include:

• Initial exacerbation of symptoms: Acne may appear to worsen during the first few weeks of treatment.
• Skin irritation:
  • Dryness
  • Peeling/Scaling
  • Redness (erythema)
  • Stinging or burning sensation on application
  • Itchiness
• Photosensitivity: Tretinoin makes the skin more sensitive to sunlight, increasing the risk of sunburn.
• Temporary hypo/hyperpigmentation: Temporary changes in skin color at the application site.
• Less common but possible severe reactions include blistering, crusting, or significant swelling.

Precautions and Warnings:

• Sun Protection: Absolutely essential. Limit sun exposure, use broad-spectrum sunscreen with high SPF daily, and wear protective clothing when outdoors.
• Avoid Irritants: Avoid concomitant use of other topical preparations that may dry or irritate the skin (e.g., medicated or drying soaps, abrasive cleansers, products with high concentrations of alcohol, astringents, lime, spices).
• Application:
  • Apply a thin layer to clean, dry affected areas, usually once daily at bedtime.
  • Avoid contact with eyes, mouth, angles of the nose, mucous membranes, or open wounds.
• Pregnancy and Breastfeeding: Contraindicated during pregnancy due to potential risks to the fetus. Women of childbearing potential should use effective contraception during treatment and for at least one month after stopping. Not recommended for use by breastfeeding women.
• Eczematous, Sunburnt, or Abraded Skin: Do not apply to these areas.
• Severe Irritation: If severe local erythema, edema, blistering, or crusting occurs, reduce frequency of application or discontinue use and consult your doctor.
• Children: Safety and efficacy in children under 12 years (for acne) or under 18 years (for photodamaged skin) may not be established; consult a doctor.
• Interactions: Inform your doctor about all other medications, supplements, and skin products you are using. Tretinoin can interact with other topical medications (e.g., benzoyl peroxide, salicylic acid, sulfur, resorcinol) and systemic medications (e.g., tetracycline antibiotics, photosensitizing medications).

Manufacturer: Diana Cream 0.025% Cream is manufactured by Panas Pharmaceutical Pvt. Ltd. in Nepal.