Deviprost

Description

Deviprost Injection (Carboprost 250mcg)

Deviprost Injection, manufactured by Dr. Reddy’s Laboratories, contains Carboprost 250 micrograms (mcg). This medication is available in Nepal.

What is Deviprost Used For?

Deviprost Injection is primarily used for:

• Terminating pregnancy during the second trimester (therapeutic abortion).
• Controlling postpartum uterine bleeding (bleeding after childbirth).

Dosage Information

Deviprost Injection is administered via intramuscular (IM) injection.

Adult Dosing:

• Pregnancy Termination (Second Trimester) / Abortion:
  • The initial dose is 250 mcg. Alternatively, a test dose of 100 mcg can be given first.
  • This dose may be repeated every 1.5 to 3.5 hours, depending on how the uterus responds.
  • If uterine contractions are not strong enough, the dose may be increased to 500 mcg.
  • The maximum total dose is 12 mg, and treatment should not exceed 2 days.
• Postpartum Hemorrhage:
  • The initial dose is 250 mcg given as a deep intramuscular injection.
  • This dose can be repeated every 15 to 90 minutes.
  • The maximum total dose is 2 mg.

Specific doses for children or those with kidney issues are not provided.

Important Considerations Before Using Deviprost

Do NOT use Deviprost if you have:

• Acute pelvic inflammatory disease.
• Active heart, lung, kidney, or liver disease.

Use with caution and inform your doctor if you have a history of:

• Glaucoma or increased pressure in the eye (IOP).
• Asthma.
• High or low blood pressure.
• Cardiovascular disease.
• Anemia.
• Jaundice.
• Kidney or liver impairment.
• Diabetes.
• Epilepsy.

Note: A temporary fever might occur due to Carboprost affecting the body’s temperature regulation. It is recommended to use antiemetic (anti-nausea) and antidiarrheal medications before or during treatment to reduce gastrointestinal side effects. Deviprost is NOT for intravenous (IV) use. Rare cases of cardiovascular collapse have been reported with prostaglandins.

Pregnancy and Lactation

• Pregnancy: Deviprost is used for pregnancy termination and to control postpartum bleeding.
• Lactation: It is unknown if Carboprost is excreted in breast milk.

Drug Interactions

• Deviprost may increase the effect of other oxytocics (medications that stimulate uterine contractions).

Possible Side Effects

Common side effects of Carboprost include:

• Gastrointestinal: Nausea (in about 1/3 of patients), Vomiting (~2/3 of patients), Diarrhea (~2/3 of patients).
• General: Nervousness, epistaxis (nosebleed), sleep disorder, hyperthermia (fever), flushing, asthma, wheezing, coughing, chest pain, hypertension (high blood pressure), syncope (fainting), palpitations, tachycardia (rapid heart rate), chest tightness, anxiety, chills/shivering, dizziness, drowsiness, dystonia, faintness, headache, lethargy, lightheadedness, vertigo.
• Other: Rash, breast tenderness, dysmenorrhea-like pain, hot flashes, dry throat, taste alterations, excessive uterine bleeding, pain at the injection site.
• Musculoskeletal: Backache, leg cramps, muscular pain, paresthesia (numbness/tingling).
• Eyes/Ears: Blurred vision, eye pain, eyelid twitching, tinnitus (ringing in ears).
• Respiratory: Bronchospasm, dyspnea (shortness of breath), hiccups.

How It Works

Carboprost is a synthetic version of a natural prostaglandin (prostaglandin F2α). It works by directly stimulating the muscles of the uterus (myometrium), causing them to contract strongly. These contractions lead to the expulsion of the products of conception during abortion and help to control bleeding after delivery by compressing blood vessels in the placenta.

Disclaimer: This information about Deviprost 250mcg Injection is provided by Farmaco Nepal drug index and is intended for general knowledge only. It is not a substitute for professional medical judgment, diagnosis, or treatment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.