Deriva Cms

Description

Deriva Cms Gel

Overview: Deriva Cms Gel is a topical medication that combines two active ingredients: Adapalene and Clindamycin. Adapalene is a retinoid-like compound that helps to normalize skin cell growth and reduce the formation of acne lesions, while Clindamycin is an antibiotic that helps to reduce acne-causing bacteria and inflammation.

Indications: Deriva Cms Gel is used for the topical treatment of:

• Mild to Moderate Inflammatory Acne Vulgaris: Acne characterized by redness and inflammation.
• Non-inflammatory Acne: Acne characterized by blackheads and whiteheads (comedones).
• Acne Vulgaris where Comedones, Papules, and Pustules Predominate: Specifically effective where blackheads, whiteheads, small red bumps (papules), and pus-filled bumps (pustules) are the main features.
• It can be used alone or in combination with other anti-acne products, as advised by your doctor in Mechinagar.

Dosage and Administration

Adults:

• Apply a thin film of gel to the affected area of the skin once daily, typically in the evening before going to bed.

Children:

• The safety and effectiveness of Deriva Cms Gel in children under the age of 12 have not been established.

Renal Dose:

• As this is a topical gel, specific dosage adjustments for kidney impairment are generally not necessary.

Administration:

• Before application, cleanse the skin with a mild soap or soap-free cleanser, then rinse thoroughly with water.
• Apply a small amount of the gel with clean fingers and gently rub it into the skin.
• Use just enough to lightly cover the entire affected area.

Important Considerations

Contraindications: Do not use Deriva Cms Gel if you have a history of hypersensitivity (allergic reaction) to:

• Clindamycin
• Lincomycin (another antibiotic related to clindamycin)
• Adapalene
• Also, do not use if you have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

Precautions:

• Systemic Absorption of Clindamycin: Even with topical application, some clindamycin can be absorbed into the body. There have been rare reports of diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis – a severe bowel inflammation) with topical clindamycin. These issues have been more commonly associated with oral or injected clindamycin, and can even start several weeks after stopping treatment. If you experience severe or bloody diarrhea, stop using the gel and contact your doctor immediately.
• Adapalene Specific Precautions:
  • Do not apply Adapalene to areas with cuts, scrapes, sunburned skin, or eczema.
  • Avoid contact with the eyes, mouth, angles of the nose, and other very sensitive areas of the body. If accidental contact occurs, immediately wash the area thoroughly with warm water.
  • Sun Sensitivity: Adapalene increases your skin’s sensitivity to sunlight and artificial UV light (like tanning beds). Avoid prolonged exposure to these. It is highly recommended to use sunscreen products (e.g., SPF 30 or higher) and wear protective clothing over treated areas when outdoors.
• Lactation (Breastfeeding): It is unknown if Adapalene or Clindamycin are excreted in breast milk when applied topically. Use with caution, and consult your doctor in Mechinagar if you are breastfeeding.

Drug Interactions:

• Clindamycin Interactions: Clindamycin has properties that can enhance the action of neuromuscular blocking agents (medications used during surgery to relax muscles). Use with caution if you are taking such agents.
• Adapalene Interactions: There are no known interactions with other medications used on the skin at the same time as Adapalene. However, other retinoids or drugs that work in a similar way to Adapalene should not be used concurrently.

Adverse Effects (Side Effects):

• Local Effects (at application site, often common): Burning sensation, itching, dryness, redness (erythema), and peeling of the skin.
• Systemic Effects (less common with topical clindamycin, but possible):
  • Cases of diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported, primarily with oral/parenteral clindamycin, but rarely with topical clindamycin.
  • Abdominal pain and other gastrointestinal disturbances, as well as Gram-negative folliculitis (inflammation of hair follicles), have also been reported with topical clindamycin.
• Adapalene Specific Side Effects (at application site):
  • Common (may affect up to 1 in 10 people): Dry skin, skin irritation, burning sensation, redness (erythema).
  • Uncommon (may affect up to 1 in 100 people): Local skin reaction (contact dermatitis), skin discomfort, sunburn, itching (pruritus), peeling skin (exfoliation), flare-up of acne (this can occur at the beginning of treatment before improvement).

Mechanism of Action:

• Clindamycin: Works by inhibiting bacterial protein synthesis. It reversibly binds to the 50S subunit of bacterial ribosomes, blocking the processes that bacteria need to build proteins. This action effectively stops the growth of susceptible bacteria, particularly P. acnes, which contributes to acne.
• Adapalene: Binds to specific retinoic acid nuclear receptors in skin cells. This binding helps to normalize the differentiation (maturation) of follicular epithelial cells, which are cells lining the hair follicles. This normalization ultimately leads to a decrease in the formation of microcomedones (tiny precursors to blackheads and whiteheads), which are the initial lesions of acne.

Note: Deriva Cms 0.1% Gel is manufactured by Glenmark Pharmaceuticals Ltd. Its generic name is Adapalene + Clindamycin Topical. Deriva Cms is available in Nepal. This information, provided by Farmaco Nepal drug index, is for general reference and is not intended for diagnosis, medical advice, or treatment. It should not be considered a substitute for the professional judgment of a healthcare provider in Mechinagar, Koshi Province, Nepal, or any other location. Always consult a qualified medical professional for specific health concerns or before starting any new medication.