Dapsone

Description

Dapsone 100 Tablet is available in Nepal. Its retail price is not specified in the provided information. Dapsone is also available in 25mg and 50mg tablet strengths under the same brand.

How to Use Dapsone 100 Tablet

Dapsone 100 Tablet is taken orally.

Adult Dosage:

• Dermatitis Herpetiformis: Start with 50 mg orally once daily, and titrate up to 300 mg once daily or higher to achieve the desired effect. The dose should be reduced to the minimum effective dose, within the range of 50-300 mg once daily, as soon as possible.
• Leprosy: 100 mg orally once daily, in combination with other anti-leprosy drugs.
  • Tuberculoid or Lepromatous Disease: 100 mg orally once daily with rifampin 600 mg orally once daily.

Child Dosage:

• Oral: 2 mg/kg, with a maximum of 100 mg every 24 hours.
• Alternatively, 4 mg/kg, with a maximum of 200 mg once weekly.

Renal Dose:

• Information regarding renal dose adjustments is not provided. Consult a healthcare professional.

Important Considerations

Contraindications:

• Do not use Dapsone 100 Tablet if you have hypersensitivity to dapsone, severe anemia, or porphyria.

Precautions:

• Use with caution in patients with G6PD deficiency, methemoglobinemia, or hemoglobin M (Hb M).
• Regular blood counts and liver function monitoring are necessary during treatment.
• Use with caution during pregnancy and lactation. Dapsone enters breast milk and is generally not recommended, though the American Academy of Pediatrics (AAP) Committee states it is “compatible with nursing.”

Interactions:

• Decreased serum concentration of dapsone may occur when used with rifampicin.
• Increased plasma concentration of dapsone may occur with probenecid and trimethoprim.
• Dapsone may antagonize clofazimine.

Potential Side Effects

Side effects of Dapsone may include:

• 1-10%: Hemolysis (destruction of red blood cells), Methemoglobinemia (a blood disorder).
• Less than 1%: Reactional states (abrupt changes in clinical activity during leprosy treatment, classified as reversal of erythema nodosum leprosum reactions), insomnia, headache, exfoliative dermatitis, photosensitivity, nausea, vomiting, anemia, leukopenia, agranulocytosis, hepatitis, cholestatic jaundice, peripheral neuropathy (more common in non-leprosy patients), blurred vision, tinnitus, Systemic Lupus Erythematosus (SLE)-like syndrome.
• Potentially Fatal: Agranulocytosis (severe reduction in white blood cells), serious cutaneous hypersensitivity reactions, exfoliative dermatitis.