Dalacin

Description

Clindamycin, the active ingredient in Dalacin Injection, is an antibiotic used to treat various bacterial infections, including:

• Dental infections
• Respiratory tract infections
• Skin and soft tissue infections
• Peritonitis
• Acne
• Anaerobic infections
• Endocarditis
• Toxic shock syndrome
• Bacterial vaginosis
• Pelvic inflammatory disease (PID)

Dosage Information

Adult Dosing:

• Serious Anaerobic Infections:
  • Oral: 150-300 mg every 6 hours; for severe infections, this can be increased to 450 mg every 6 hours. The maximum daily dose is 1.8 grams.
  • Intravenous (IV): 0.6-2.7 grams per day, divided into multiple doses; for severe infections, up to 4.8 grams per day.
• Endocarditis Prophylaxis (before dental procedures): 600 mg orally, 1 hour before the procedure.
• Toxic Shock Syndrome: 900 mg every 8 hours (when used with penicillin G or ceftriaxone).
• Pelvic Inflammatory Disease (PID): 900 mg every 8 hours (when used with gentamicin).
• Bacterial Vaginosis: 300 mg orally every 12 hours for 7 days.

Child Dosing:

• Neonates (less than 1 month): 15-20 mg/kg/day, divided into 3 to 4 equal doses. Smaller premature infants may need a lower effective dosage.
• Children (Oral):
  • 10-25 mg/kg/day every 8 hours.
  • 30-40 mg/kg/day for specific infections like CA-MRSA (Community-Acquired Methicillin-Resistant Staphylococcus aureus), intra-abdominal infections, or Acute Otitis Media (AOM).
• Children (Parenteral – IV/IM): 20-40 mg/kg/day every 8 hours. Higher doses are reserved for more severe infections.

Administration

• Capsules: Can be taken with or without food. Swallow the capsule whole with a full glass of water while remaining in an upright position.
• Granules: Should be taken with food.

Intravenous (IV) Administration:

• Preparation:
  • Dilute 300 mg and 600 mg doses in 50 mL of D5W.
  • Dilute 900 mg in 50-100 mL of D5W.
  • Dilute 1200 mg in 100 mL of D5W.
• Infusion (Intermittent): Infuse over 10-60 minutes, ensuring the rate does not exceed 30 mg/minute.
  • 300 mg doses should infuse over 10 minutes.
  • 600 mg doses should infuse over 20 minutes.
  • 900 mg doses should infuse over 30 minutes.
  • 1200 mg doses should infuse over 60 minutes.
  • Important: No more than 1200 mg of the drug should be given by IV infusion in one hour.