Cxime

Description

Cxime D-SY (Cefixime)

Description: Cxime D-SY contains Cefixime, an antibiotic that belongs to the cephalosporin class.

Indications: Cxime D-SY is used for the treatment of various susceptible bacterial infections, including:

• Respiratory Tract Infections: Such as pneumonia, pharyngitis, sinusitis, tonsillitis, acute bronchitis, and acute exacerbations of chronic bronchitis.
• Ear Infections: Otitis media.
• Soft Tissue Infections.
• Typhoid Fever.
• Uncomplicated Gonococcal Urethritis.

Dosage and Administration:

Adults:

• For Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, and Uncomplicated Urinary Tract Infections: The recommended dose is 200 mg or 400 mg daily, administered as a single dose or in two divided doses.
• For Gonorrhea (Uncomplicated): A single dose of 400 mg.
• For Typhoid Fever: 20 mg/kg body weight daily, divided into two doses. The usual treatment duration is 7 days, which may be extended up to 14 days depending on the severity of the infection.

Children:

• General Dosing (for children weighing less than 50 kg): 8 mg/kg/day orally, administered every 12 to 24 hours.
• For Convalescent Oral Therapy of Serious Infections: Up to 20 mg/kg/day.
• For Powder for Suspension & DS Powder for Suspension (Specific Age-Based Dosing):
  • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
  • 6 months – 1 year: 75 mg daily.
  • 1 – 4 years: 100 mg daily.
  • 5 – 10 years: 200 mg daily.
• For Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days; the total daily dose should not exceed 400 mg.
• Children < 6 months: Safety and efficacy have not been established in this age group.

Renal Impairment:

• A dose reduction is necessary for patients with renal impairment.
• For a Creatinine Clearance (CrCl) of less than 20 mL/min, the maximum daily dose should be 200 mg.

Administration: Cxime D-SY can be taken with or without food. Taking it with food or milk may help reduce gastrointestinal discomfort.

Contraindications:

• Known hypersensitivity to cephalosporins.

Precautions:

• Exercise caution in patients with a history of allergy to penicillins.
• Use with care during pregnancy and lactation.
• Special consideration is required for patients with renal failure or gastrointestinal (GI) disease.

Lactation: It is unknown whether Cefixime is excreted in breast milk.

Drug Interactions:

• Probenecid: May lead to increased concentrations of Cefixime.
• Anticoagulants: May potentially increase prothrombin time. Close monitoring is advised.

Adverse Effects:

• Common (>10%): Diarrhea (16%).
• Frequency Not Defined (may include): Abdominal pain, candidiasis, dizziness, dyspepsia, elevated transaminases, eosinophilia, erythema multiforme, fever, flatulence, headache, increased blood urea nitrogen (BUN), increased creatinine, leukopenia, nausea, prolonged prothrombin time (PT), pruritus, pseudomembranous colitis, rash, serum sickness-like reaction, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis, and vomiting.
• Potentially Fatal: Pseudomembranous colitis.

Mechanism of Action: Cefixime works by binding to one or more of the penicillin-binding proteins (PBPs) in the bacterial cell wall. This action inhibits the final transpeptidation step of peptidoglycan synthesis, which is crucial for bacterial cell wall formation. By inhibiting biosynthesis and arresting cell wall assembly, Cefixime ultimately leads to bacterial cell death.

Note: Cxime D-SY is manufactured by Arya Pharma Lab Pvt. Ltd. Its generic name is Cefixime. Cxime is available in Nepal. This drug information is provided for general understanding and is not intended for diagnosis, medical advice, or treatment, nor is it a substitute for the exercise of professional judgment. Always consult with a healthcare professional for any health concerns.