Cosmelite-S

Description

Cosmelite-S Ointment: A Topical Treatment for Skin Conditions

Cosmelite-S Ointment, manufactured by Maruti Pharma Pvt. Ltd. in Nepal, is a topical ointment containing a combination of Clobetasol Propionate 0.05% w/w and Salicylic Acid 3.0% w/w. It’s used to treat various skin conditions such as psoriasis, eczema, dyskeratosis, ichthyosis, hyperkeratosis, scaly skin disease, and dermatitis. It can also be applied for acne vulgaris, warts, corns, calluses, seborrhea, hair loss, and sweating feet.

The retail price for Cosmelite-S Ointment is not specified. Other brands with similar active ingredients available in Nepal include Cloderm S, Dipsalic F, and SOLBE-S.

How to Use Cosmelite-S Ointment

Cosmelite-S Ointment is for topical application only.

Adult Dosage:

• Acne; Hyperkeratotic and scaling skin conditions: Apply more than 3 times daily.
• Warts and calluses: Apply as directed by a healthcare professional.

Important Considerations

Contraindications:

• Do not use Cosmelite-S Ointment if you have a hypersensitivity to any of its ingredients.

Precautions:

• Do not use for prolonged periods in high concentrations or on large areas of the body.
• Use with caution if you have impaired peripheral circulation or diabetes.
• Avoid contact with broken skin, mouth, eyes, mucous membranes, and the anogenital region.

Pregnancy and Lactation:

• Information regarding use during pregnancy and lactation is not provided; consult a healthcare professional.

Interactions:

• Clobetasol Propionate: Systemic exposure may increase when used with CYP3A4 inhibitors (e.g., ritonavir and itraconazole).

Potential Side Effects

Prolonged usage of large amounts of Clobetasol Propionate and Salicylic Acid topical can lead to:

• Adrenal suppression, Cushing’s syndrome, diabetes, and hypertension due to sufficient systemic levels of clobetasol propionate.
• Dermal and epidermal atrophy, especially on the face.
• Steroid purpura.

How Cosmelite-S Ointment Works

Clobetasol Propionate is a high-potency corticosteroid. It reduces inflammation by:

• Stabilizing leukocyte lysosomal membranes.
• Preventing the release of destructive acid hydrolases from leukocytes.
• Inhibiting macrophage accumulation in inflamed areas.
• Reducing leukocyte adhesion to capillary endothelium.
• Reducing capillary wall permeability and edema formation.
• Decreasing complement components.
• Antagonizing histamine activity and kinin release.
• Reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.

Salicylic Acid has a potent keratolytic action and a slight antiseptic effect when applied topically. It works by:

• Softening and destroying the stratum corneum (the outermost layer of skin) by increasing endogenous hydration.
• Causing the horny layer of the skin to swell, soften, and then desquamate (peel off).
• At high concentrations, salicylic acid has a caustic effect.
• It also possesses weak antifungal and antibacterial activity.