₨ NPR
Controx
Controx Injection: Quick Overview
Controx Injection contains Ceftriaxone 1gm and is made by Concept Pharmaceuticals Ltd. It costs ₨ 90.00 NPR and is available in Nepal.
What it’s for & How to Take It
- Uses: Treats serious bacterial infections like pneumonia, meningitis, ear infections, typhoid fever, bloodstream infections, skin infections, UTIs, bone/joint infections, gonorrhea, and is used to prevent surgical infections.
- Adults: Usually 1-2 g daily (up to 4 g for severe cases) given IV or IM. Doses vary for specific conditions (e.g., 2 g IV every 12 hours for meningitis, single 250 mg IM for uncomplicated gonorrhea).
- Children: Dosing is based on weight (e.g., 50–75 mg/kg/day, max 2g/day). For meningitis, it can go up to 100 mg/kg/day (max 4g/day).
- Kidney Issues: Dose adjustments are needed; maximum 2g daily if kidney function is very low.
- Administration: Given intravenously (into a vein, over 30 minutes) or as a deep intramuscular injection (into a large muscle).
Important Things to Know
- Don’t use if: You’re allergic to cephalosporins or if you’re a jaundiced newborn.
- CRITICAL WARNING: Never use with calcium-containing IV solutions within 48 hours; this can lead to fatal precipitates in the lungs and kidneys.
- Be careful if: You have a history of penicillin allergy, severe kidney problems, or are pregnant/breastfeeding.
- Interactions: Can increase the kidney toxicity of aminoglycosides, reduce the effectiveness of certain vaccines, and enhance the effect of blood thinners (like warfarin).
- Side Effects: Pain and hardening at the injection site are common. Other effects include diarrhea, rash, and changes in blood counts. A rare, but serious, side effect is pseudomembranous colitis.
- How it works: Kills bacteria by preventing them from building their cell walls.
₨90.00
Ask about productDescription
Controx Injection
Ceftriaxone
1gm
Concept Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 90.00 NPR |
Indications
Controx Injection is used for: Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure Infections, Gonorrhea, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Chlamydia infection, Surgical Prophylaxis
Adult Dose
Susceptible infections IV/IM 1-2 g/day, up to 4 g/day for severe infections. Intra-abdominal Infections Complicated, mild-to-moderate, community acquired: 1-2 g/day IV in single daily dose or divided q12hr for 4-7 days, in combination with metronidazole Meningitis 2 g IV q12hr for 7-14 days Acute Uncomplicated Pyelonephritis 1-2 g IV qDay Typhoid fever 2 g IV once daily for 14 days. Surgical Prophylaxis Prophylaxis of surgical infection 1 g IV 0.5-2 hours before procedure Uncomplicated Gonococcal Infections Uncomplicated gonococcal infection of pharynx, cervix, urethra, or rectum: ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively, doxycycline 100 mg PO q12hr for 7 days Pelvic Inflammatory Disease 250 mg IM as single dose with doxycycline, with or without metonidazole for 14 days
Child Dose
Children: IV, IM: 50–75 mg/kg/day, max 2 g/day q24h 50 mg/kg, max 1 g, 1–3 doses IM for AOM q24h 100 mg/kg/day for meningitis, max 4 g/day q12h
Renal Dose
Renal impairment: CrCl (ml/min) <10 Max: 2 g daily.
Administration
IV/IM Administration IV: Infuse intermittently over 30 minutes IM: Inject deep into large muscle mass
Contra Indications
Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.
Precautions
History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection. Lactation: Drug enters breast milk in low concentrations; use with caution
Pregnancy-Lactation
Interactions
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid. Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.
Adverse Effects
Side effects of Ceftriaxone : >10% Induration after IM injection (5-17%) 1-10% Eosinophilia (6%),Thrombocytosis (5%),Diarrhea (3%),Elevated hepatic transaminases (3%),Leukopenia (2%),Rash (2%),Increased blood urea nitrogen (BUN) (1%),Induration at IV site (1%),Pain (1%) <1% Agranulocytosis,Anaphylaxis,Anemia,Basophilia,Bronchospasm,Candidiasis,Chills,Diaphoresis,Dizziness,Dysgeusia,Flushing,Gallstones,Glycosuria,Headache,Hematuria,Hemolytic anemia,Increased alkaline phosphatase or bilirubin,Increased creatinine,Jaundice,Leukocytosis,Lymphocytosis,Lymphopenia,Monocytosis,Nausea,Neutropenia,Phlebitis,Prolonged or decreased prothrombin time (PT),Pruritus,Renal stones,Serum sickness,Thrombocytopenia,Urinary casts,Vaginitis,Vomiting
Mechanism of Action
Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Controx 1gm Injection manufactured by Concept Pharmaceuticals Ltd.. Its generic name is Ceftriaxone. Controx is availble in Nepal. Farmaco Nepal drug index information on Controx Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Additional information
| form | Oral Tablets |
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