Clinpar A

Description

Clinpar A Gel is indicated for the topical treatment of mild to moderate inflammatory acne vulgaris, as well as non-inflammatory acne. It can be used alone or in combination with other anti-acne products, particularly when comedones (blackheads/whiteheads), papules (small red bumps), and pustules (pus-filled bumps) are the predominant acne lesions.

Dosage & How to Use

Adult Dose:

• Apply a thin film of the gel to the affected area of the skin once daily in the evening, before going to bed.

Child Dose:

• The safety and effectiveness of Clinpar A Gel in children under 12 years of age have not been established.

Application Instructions:

1. Cleanse your skin with a mild soap or a soap-free cleanser.
2. Rinse your skin with water.
3. Apply a small amount of gel with clean fingers and gently rub it into the skin.
4. Use just enough gel to lightly cover the entire affected area.

Important Considerations

• Contraindications: Do not use Clinpar A Gel if you have a history of:
  • Hypersensitivity (allergy) to clindamycin, lincomycin, or adapalene.
  • Regional enteritis (a type of inflammatory bowel disease).
  • Ulcerative colitis.
  • Antibiotic-associated colitis.
• Precautions:
  • Clindamycin Absorption: Even with topical application, clindamycin can be absorbed from the skin surface. Cases of diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with both topical and systemic clindamycin. These gastrointestinal issues can sometimes begin up to several weeks after stopping oral or injected clindamycin.
  • Adapalene Use:
    • Avoid applying the gel to areas with cuts, scrapes, sunburned skin, or eczema.
    • Avoid contact with your eyes, mouth, angles of the nose, and other very sensitive body areas. If accidental contact occurs, wash immediately with warm water.
    • Sun Sensitivity: Limit exposure to strong sunlight and artificial UV light (like tanning beds). It’s recommended to use sunscreen products and wear protective clothing over treated areas.
• Lactation (Breastfeeding): It’s unknown if the active ingredients are excreted in breast milk. Use with caution if breastfeeding.
• Drug Interactions:
  • Clindamycin: Has neuromuscular blocking properties. Use with caution if you are also taking other neuromuscular blocking agents, as clindamycin may enhance their effects.
  • Adapalene: There are no known interactions with other medications that might be used cutaneously and concurrently with Adapalene. However, avoid using other retinoids or drugs with a similar mechanism of action concurrently with adapalene to prevent excessive skin irritation.
• Adverse Effects (Side Effects):
  • Local Effects (Common): Burning, itching, dryness, redness (erythema), and peeling at the application site.
  • Systemic Effects (Rare with Topical Clindamycin but reported): Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis). Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis, have also been reported.
  • Adapalene-Specific Side Effects:
    • Common (may affect up to 1 in 10 people): Dry skin, skin irritation, burning sensation, redness (erythema).
    • Uncommon (may affect up to 1 in 100 people): Local skin reaction (contact dermatitis), skin discomfort, sunburn, itching (pruritus), peeling skin (exfoliation), and flare-up of acne.
• Mechanism of Action:
  • Clindamycin: Works by stopping bacterial growth. It binds to the 50S ribosomal subunit of susceptible bacteria, blocking protein synthesis necessary for their survival and reproduction. This helps control the bacterial component of acne.
  • Adapalene: A retinoid-like compound that binds to specific retinoic acid nuclear receptors. This action helps to normalize the growth and differentiation of follicular epithelial cells, which ultimately reduces the formation of microcomedones (the earliest type of acne lesion).