Ciplactin

Description

Ciplactin Syrup is used for several conditions, including:

• Rash and pruritus (itching) associated with various conditions.
• Appetite stimulation and treatment of anorexia nervosa.
• Management of certain endocrine disorders like Cushing’s and Nelson’s syndrome, acromegaly, and hyperprolactinemia.
• Treatment and prevention of migraine and other vascular headaches.
• Addressing antidepressant-induced anorgasmia.

Dosage Information

You can take Ciplactin with or without food. Taking it with meals may help reduce any stomach discomfort.

Adult Dose

• Allergic Conditions:
  • Initially: 4 mg three times a day (tid), adjusting as needed.
  • Usual: 12-16 mg daily, divided into 3-4 doses.
  • Maximum: 32 mg/day.
• Treatment and Prophylaxis of Migraine and Other Vascular Headaches:
  • 4 mg, which you can repeat after 30 minutes.
  • Do not exceed 8 mg within a 4- to 6-hour period.
  • Maintenance: 4 mg every 4-6 hours.

Child Dose

• Allergic Conditions:
  • 2-6 years: 2 mg two or three times a day (bid or tid). Maximum: 12 mg daily.
  • 7-14 years: 4 mg two or three times a day (bid or tid). Maximum: 16 mg daily.
• Migraine Prophylaxis:
  • Under 3 years: The safety and effectiveness of this medication have not been established for this age group.
  • Over 3 years and Adolescents: 0.2-0.4 mg/kg/day orally, divided twice a day (BID). Do not exceed 0.5 mg/kg/day.

Important Considerations

Contraindications

Do not use Ciplactin Syrup if you have:

• Narrow-angle glaucoma.
• An acute asthmatic attack.
• Bladder neck obstruction.
• Stenosing peptic ulcer.
• Gastrointestinal tract (GIT) obstruction.
• Are currently undergoing MAOI (Monoamine Oxidase Inhibitor) therapy.
• Hypersensitivity to Cyproheptadine HCl.
• This medication is contraindicated in neonates and during lactation.

Precautions

Use Ciplactin Syrup with caution if you are:

• Elderly.
• Performing tasks that require mental alertness.
• Experiencing symptomatic prostate hypertrophy.
• Have epilepsy or alcoholism.
• Pregnant.

Pregnancy and Lactation

• Pregnancy: Use with caution.
• Lactation: It is unknown if octreotide crosses into breast milk; therefore, avoid giving to lactating women.

Interactions

• Ciplactin may have additive effects when taken with CNS depressants such as hypnotics, sedatives, tranquilizers, and anti-anxiety agents.
• Potentially Fatal Interaction: MAOIs can prolong and intensify the anticholinergic effects of antihistamines.

Adverse Effects (Side Effects)

Common side effects of Cyproheptadine HCl include:

• Psychiatric/Neurologic: CNS depression, drowsiness, sedation (ranging from mild to deep sleep, most frequent), dizziness, lassitude, disturbed coordination. Less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia.
• Muscular: Weakness.
• Cardiovascular: Palpitation, tachycardia, ECG changes (e.g., widened QRS), arrhythmias (e.g., extrasystole, heart block), hypotension, hypertension.
• Gastrointestinal (GI): Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation.
• Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare).
• Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin.
• Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis.
• Renal: Dysuria, urinary retention.
• Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness.
• Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness.

Mechanism of Action

Cyproheptadine is a sedating antihistamine with antimuscarinic, serotonin antagonist, and calcium channel blocking properties. It works by competing with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels, and respiratory tract.