Chexid

Description

Chexid Capsule

Chexid Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Aristo Pharmaceuticals Ltd. It’s available in Nepal.

Uses (Indications)

Chexid Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcers (in the stomach or duodenum)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus due to acid reflux)

How it Works (Mechanism of Action)

Lansoprazole, a substituted benzimidazole, is a proton pump inhibitor (PPI). It works by blocking the final step of acid secretion in the stomach’s parietal cells, specifically by inhibiting the H+/K+ ATPase enzyme system. This reduces both basal (resting) and stimulated acid production.

Dosage Information

Administration: Chexid Capsule should be taken on an empty stomach, preferably before meals.

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Initially, 60 mg once daily in the morning. Doses greater than 120 mg daily should be divided into two doses. Adjust as needed.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week Triple Therapy): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily and Amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and Metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Hepatic Impairment: For severe hepatic impairment, the maximum dose is 30 mg per day.
• Renal Impairment: No dosage adjustment is needed.

Children:

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Less than 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • More than 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses may be increased up to 30 mg twice daily if symptoms persist after 2 or more weeks of treatment.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD) or 30 mg once daily for up to 8 weeks (for erosive oesophagitis).

Important Considerations

Do Not Use If You Have (Contraindications):

• Known hypersensitivity to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment.
• A gastric malignancy should be ruled out before starting treatment, as symptoms of gastric malignancy may be masked by Lansoprazole.
• Pregnancy and Lactation: Not known whether Lansoprazole is distributed into breast milk; breastfeeding is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesemia: With diuretics and digoxin.
• Decreased Plasma Concentration of Other Drugs: Erlotinib, dasatinib, lapatinib.
• Decreased Bioavailability: Itraconazole and ketoconazole.
• Increased Plasma Concentration: Cilostazol and methotrexate.
• Reduced Bioavailability: Antacids and sucralfate may reduce the absorption of Chexid; take Chexid at least 30 minutes before antacids or sucralfate.

Potentially Fatal Interactions:

• May significantly decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety
• Angina
• Palpitations
• Syncope
• Edema
• Anorexia
• Dry mouth
• Tenesmus
• Flatulence
• Melena (dark, tarry stools)
• Myalgia (muscle pain)
• Tinnitus (ringing in the ears)
• Allergic reactions

Disclaimer: This information about Chexid Capsule is for general knowledge and informational purposes only and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment