bezalip 200 mg

Description

Bezalip 200 mg – Detailed Description

Generic Name: Bezafibrate
Brand Name: Bezalip 200 mg
Dosage Form: Tablet
Strength: 200 mg

Pharmacological Class:
Bezalip 200 mg contains bezafibrate, which belongs to the class of medications known as fibrates or fibric acid derivatives. These drugs primarily act as lipid-lowering agents.

Mechanism of Action:
Bezalip (bezafibrate) works by activating peroxisome proliferator-activated receptors (PPARs), particularly PPAR-alpha. Activation of PPAR-alpha leads to an increase in the oxidation of fatty acids and a decrease in the synthesis of triglycerides in the liver. This results in a reduction of serum triglycerides and very-low-density lipoprotein (VLDL) cholesterol levels. It also causes a moderate increase in high-density lipoprotein (HDL) cholesterol, which is beneficial for cardiovascular health.

Indications:
Bezalip 200 mg is primarily prescribed for the management of various types of dyslipidemia, including:

• Hypertriglyceridemia (elevated triglyceride levels)

• Mixed dyslipidemia (elevated cholesterol and triglycerides)

• Primary hypercholesterolemia (elevated LDL cholesterol)

• Prevention of cardiovascular disease in patients with lipid disorders

It is usually used alongside dietary modifications and lifestyle changes, such as diet, exercise, and weight control, to help manage abnormal blood lipid levels.

Dosage and Administration:
The typical dosage of Bezalip 200 mg tablets is one tablet taken orally once or twice daily, depending on the patient’s condition and doctor’s recommendation. Tablets should be taken with food to improve absorption and reduce gastrointestinal side effects.

Contraindications:
Bezalip 200 mg should not be used in patients with:

• Severe liver or kidney impairment

• Gallbladder disease, including gallstones

• Hypersensitivity to bezafibrate or other fibrates

• Pregnancy and breastfeeding unless specifically advised by a healthcare professional

Precautions and Warnings:

• Regular monitoring of liver function tests, kidney function, and blood counts is recommended during therapy.

• Patients should report any unexplained muscle pain, tenderness, or weakness, which could indicate a rare but serious side effect called rhabdomyolysis.

• Caution is advised when used concurrently with statins or other lipid-lowering agents to reduce the risk of muscle toxicity.

Side Effects:
Common side effects may include:

• Gastrointestinal disturbances such as nausea, abdominal pain, and diarrhea

• Headache and dizziness

• Elevated liver enzymes

• Rarely, muscle-related symptoms (myopathy or rhabdomyolysis)

• Skin rash or allergic reactions in some individuals

Storage:
Store Bezalip 200 mg tablets at room temperature, away from moisture, heat, and direct sunlight. Keep out of reach of children.