Atoin

Description

Atoin Tablet: Tretinoin Topical 0.025% w/w

Atoin Tablet is a topical medication containing Tretinoin at a concentration of 0.025% w/w, manufactured by Asian Pharmaceuticals Pvt. Ltd. It is available in Nepal with a retail price of 120.00 NPR.

What is Atoin Tablet used for?

Atoin Tablet is primarily used to treat:

• Acne
• Mottled hyperpigmentation
• Roughness and fine wrinkling of photodamaged skin

How do you use Atoin Tablet?

Atoin Tablet is for topical/cutaneous use only.

Adult Dose:

• Acne Vulgaris: Apply once daily, usually at bedtime, to the affected area after it has been thoroughly cleansed and dried to remove excess oil. You may start to see improvements after 6-8 weeks of consistent use.
• Mottled hyperpigmentation, roughness, and fine wrinkling of photodamaged skin: Apply a pea-sized amount to your entire face once daily at night. It may take up to 6 months to see a therapeutic response.

Child Dose:

• Acne Vulgaris:
  • Under 12 years: The safety and effectiveness of Atoin Tablet have not been established for children under 12 years of age.
  • Over 12 years: Apply once daily, usually at bedtime, to the affected area.

Important Considerations

Do not use Atoin Tablet if:

• You are hypersensitive to retinoids.
• You have eczematous, sunburnt, or abraded skin.
• You are pregnant or breastfeeding.

Precautions:

• Avoid using other topical applications at the same time, especially those with keratolytic agents.
• Limit exposure to sunlight, UV light, and extreme weather conditions (e.g., cold).
• Keep the medication away from your eyes, mouth, nose corners, mucous membranes, or open wounds.
• If you experience severe local redness, swelling, blistering, or crusting, reduce the frequency of application or discontinue use.
• Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing, and harsh scrubbing.
• Do not use topical preparations with high concentrations of alcohol, menthol, spices, or lime.

Pregnancy and Lactation: Atoin Tablet is contraindicated during pregnancy and lactation.

Potential Interactions with Other Medications

Atoin Tablet can interact with other medications, potentially leading to:

• Enhanced absorption of minoxidil.
• Increased risk of fatal blood clots with antifibrinolytics.
• Increased tretinoin concentrations when used with azole antifungals.
• Enhanced peeling action when used with sulfur, resorcinol, benzoyl peroxide, or salicylic acid.
• Increased photosensitivity with photosensitizing medications such as thiazides, tetracyclines, fluoroquinolones, phenothiazines, and sulfonamides.
• Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.

Possible Side Effects

Common side effects of Tretinoin Topical may include:

• Initial worsening of symptoms
• Skin irritation
• Stinging upon application
• Swelling (oedema)
• Blistering
• Crusting of the skin
• Redness (erythema)
• Scaling
• Photosensitivity
• Temporary lightening or darkening of the skin (hypo/hyperpigmentation)

How does Atoin Tablet work?

Tretinoin, a trans-retinoic acid form of Vitamin A, works by:

• Stimulating mitosis and turnover of follicular epithelial cells, which reduces their stickiness. This helps to expel existing blackheads and whiteheads and prevent new ones from forming.
• Thinning the outermost layer of the skin (stratum corneum).
• In acute promyelocytic leukemia, it also induces cellular differentiation and decreases proliferation.