Aryadine

Description

Aryadine Solution: Clinical Information

Aryadine Solution, containing Povidone Iodine 5% Topical, is indicated for:

• Treatment of primary or secondary topical infections, including infected surgical incisions, decubitus or stasis ulcers, pyodermas, secondarily infected dermatoses, and infected traumatic lesions.
• Prevention of infections in cuts, abrasions, and wounds.

Dosage and Administration (Adults)

• As Ointment:
  • For the treatment of infection: Apply once or twice daily, or at dressing changes, for a maximum of 14 days.
  • For the prevention of infection: Apply once or twice a week for as long as necessary.
  • Apply the ointment directly to the affected area after it has been cleaned and dried. The treated area may be covered with a dressing or bandage.
• As Powder: Apply as often as required. May be covered with a dressing or bandage.

Contraindications

Regular use of Aryadine Solution is contraindicated in:

• Patients with thyroid disorders (specifically nodular colloid goitre, endemic goitre, and Hashimoto’s thyroiditis).
• Infants under 2 years of age.
• Special caution is needed when regular applications to broken skin are made to patients with pre-existing renal insufficiency.
• Regular use should be avoided in patients on concurrent lithium therapy.

Precautions

• Use with caution during pregnancy and lactation.
• Exercise caution when used in neonates.

Adverse Effects

Side effects of Povidone Iodine 5% Topical can include:

• Local skin irritation and sensitivity.
• Application to large areas of denuded skin may lead to systemic effects due to iodine absorption.
• Application to large wounds or severe burns may produce systemic adverse effects such as metabolic acidosis, hypernatraemia, and impairment of renal function.
• Occasionally, mild-transient burning or sticky sensation.
• Very rarely, irritation or hypersensitivity reactions are reported.

Mechanism of Action

Povidone-iodine is an iodophore that exhibits powerful broad-spectrum germicidal activity against a wide range of bacteria, viruses, fungi, protozoa, and spores. Its microbicidal action occurs by oxidizing cell constituents, iodinating proteins, and subsequently inactivating them.

Note: Aryadine 5% Solution is manufactured by Arya Pharma Lab Pvt. Ltd. Its generic name is Povidone Iodine 5% Topical. Aryadine is available in Nepal. This information from the Farmaco Nepal drug index is not intended for diagnosis, medical advice, or treatment; neither is it a substitute for the exercise of professional judgment.