AROFIX

Description

AROFIX Dry Syrup (Cefixime)

Description: AROFIX Dry Syrup contains Cefixime, a cephalosporin antibiotic.

Indications: AROFIX Dry Syrup is indicated for the treatment of susceptible bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, Pharyngitis, Sinusitis, Tonsillitis, Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis.
• Ear Infections: Otitis Media.
• Soft Tissue Infections.
• Typhoid Fever.
• Gonococcal Urethritis (uncomplicated).

Dosage and Administration:

Adults:

• Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg to 400 mg daily, administered as a single dose or in two divided doses.
• Gonorrhea (Uncomplicated): 400 mg as a single dose.
• Typhoid Fever: 20 mg/kg body weight daily, in two divided doses. The usual treatment duration is 7 days, which may be extended up to 14 days based on infection severity.

Children:

• General Dosing (for children weighing less than 50 kg): 8 mg/kg/day orally, administered every 12 to 24 hours.
• Convalescent Oral Therapy for Serious Infections: Up to 20 mg/kg/day.
• Powder for Suspension & DS Powder for Suspension (Specific Age-Based Dosing):
  • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
  • 6 months – 1 year: 75 mg daily.
  • 1 – 4 years: 100 mg daily.
  • 5 – 10 years: 200 mg daily.
• Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours, for 7-14 days. Do not exceed 400 mg/day.
• Children < 6 months: Safety and efficacy have not been established.

Renal Impairment: Dose reduction is necessary.

• Creatinine Clearance (CrCl) < 20 mL/min: Maximum 200 mg daily.

Administration: AROFIX Dry Syrup may be taken with or without food. Taking with food or milk may help reduce gastrointestinal discomfort.

Contraindications:

• Hypersensitivity to cephalosporins.

Precautions:

• Patients with a history of allergy to penicillins.
• Pregnancy.
• Lactation.
• Renal failure.
• Gastrointestinal disease.

Pregnancy and Lactation:

• Lactation: It is unknown whether Cefixime is excreted in breast milk.

Drug Interactions:

• Probenecid: May increase Cefixime concentrations.
• Anticoagulants: May potentially increase prothrombin time; monitor closely.

Adverse Effects:

• Common (>10%): Diarrhea (16%).
• Frequency Not Defined (may include): Abdominal pain, Candidiasis, Dizziness, Dyspepsia, Elevated transaminases, Eosinophilia, Erythema multiforme, Fever, Flatulence, Headache, Increased blood urea nitrogen (BUN), Increased creatinine, Leukopenia, Nausea, Prolonged prothrombin time (PT), Pruritus, Pseudomembranous colitis, Rash, Serum sickness-like reaction, Stevens-Johnson syndrome, Thrombocytopenia, Urticaria, Vaginitis, Vomiting.
• Potentially Fatal: Pseudomembranous colitis.

Mechanism of Action: Cefixime exerts its bactericidal effect by binding to one or more penicillin-binding proteins (PBPs). This action inhibits the final transpeptidation step of peptidoglycan synthesis, a crucial component of the bacterial cell wall. This inhibition leads to the arrest of cell wall assembly and ultimately, bacterial cell death.

Note: AROFIX 50MG/5ML Dry Syrup is manufactured by Arrow Pharmaceuticals Pvt Ltd. Its generic name is Cefixime. AROFIX is available in Nepal. This information is provided for general understanding and is not intended for diagnosis, medical advice, or treatment, nor is it a substitute for professional medical judgment.