AROFIX DT

Description

AROFIX DT Tablet (Cefixime)

Indications:

• Pneumonia
• Pharyngitis
• Typhoid Fever
• Susceptible Infections (General)
• Sinusitis
• Otitis Media
• Tonsillitis
• Soft Tissue Infections
• Respiratory Tract Infections (including Acute Exacerbations of Chronic Bronchitis and Acute Bronchitis)
• Gonococcal Urethritis (Uncomplicated)
• Uncomplicated Urinary Tract Infections

Dosage and Administration:

• Adults:
  • Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg daily as a single dose or in two divided doses.
  • Gonorrhea: 400 mg as a single dose.
  • Typhoid Fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, which may be continued for up to 14 days according to the severity of the infection.
• Children:
  • Oral Suspension/DS Powder for Suspension:
    • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
    • 6 months – 1 year: 75 mg daily.
    • 1-4 years: 100 mg daily.
    • 5-10 years: 200 mg daily.
  • General Dosing for Children (<50 kg): 8 mg/kg/day orally, every 12-24 hours. For convalescent oral therapy of serious infections, up to 20 mg/kg/day.
  • Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days; not to exceed 400 mg/day.
  • Children <6 months: Safety and efficacy have not been established.

Renal Impairment: Dose reduction is necessary.

• Creatinine Clearance (CrCl) <20 mL/min: Maximum 200 mg daily.

Method of Administration: May be taken with or without food. May be taken with food or milk to reduce gastrointestinal discomfort.

Contraindications:

• Hypersensitivity to cephalosporins.

Precautions:

• History of allergy to penicillins.
• Pregnancy.
• Lactation.
• Renal failure.
• Gastrointestinal disease.
• Lactation: Unknown whether the drug is excreted in milk; use with caution.

Pregnancy and Lactation:

• Pregnancy: Use with caution.
• Lactation: Unknown whether the drug is excreted in milk; use with caution.

Interactions:

• Increased cefixime concentrations with probenecid.
• Potentially Fatal: May increase prothrombin time with anticoagulants.

Adverse Effects:

• Common (>10%): Diarrhea (16%).
• Frequency Not Defined: Abdominal pain, candidiasis, dizziness, dyspepsia, elevated transaminases, eosinophilia, erythema multiforme, fever, flatulence, headache, increased blood urea nitrogen (BUN), increased creatinine, leukopenia, nausea, prolonged prothrombin time (PT), pruritus, pseudomembranous colitis, rash, serum sickness-like reaction, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis, vomiting.
• Potentially Fatal: Pseudomembranous colitis.

Mechanism of Action: Cefixime binds to one or more of the penicillin-binding proteins (PBPs), which inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall. This action inhibits biosynthesis and arrests cell wall assembly, resulting in bacterial cell death.

Notes: AROFIX DT 100mg Tablet is manufactured by Arrow Pharmaceuticals Pvt Ltd. Its generic name is Cefixime. AROFIX DT is available in Nepal.

Disclaimer: This information is not intended for diagnosis, medical advice, or treatment and should not be considered a substitute for the exercise of professional judgment by a qualified healthcare provider.