AROFIX-100

Description

AROFIX-100 Dry Syrup, manufactured by Arrow Pharmaceuticals Pvt Ltd in Nepal, is a 100 MG/5ML oral suspension containing the antibiotic Cefixime. It is used to treat a variety of bacterial infections, including pneumonia, pharyngitis, typhoid fever, sinusitis, otitis media, tonsillitis, soft tissue infections, respiratory tract infections, acute exacerbations of chronic bronchitis, acute bronchitis, and gonococcal urethritis.

AROFIX-100 Dry Syrup is available for 180.00 NPR. Cefixime is also available in Nepal under other brands and in various forms, including 50MG/5ML Dry Syrup, 100mg, 200mg, and 400mg tablets.

How to Use AROFIX-100 Dry Syrup

AROFIX-100 Dry Syrup can be taken with or without food; taking it with food or milk may help reduce gastrointestinal discomfort.

Adult Dosage:

• Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg daily as a single dose or in two divided doses.
• Gonorrhea: 400 mg as a single dose.
• Typhoid Fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, but it may be extended up to 14 days depending on the infection’s severity.

Child Dosage:

• Children weighing less than 50 kg: 8 mg/kg/day orally, every 12-24 hours. For convalescent oral therapy of serious infections, up to 20 mg/kg/day may be used.
• Powder for Suspension & DS Powder for Suspension:
  • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
  • 6 months-1 year: 75 mg daily.
  • 1-4 years: 100 mg daily.
  • 5-10 years: 200 mg daily.
• Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days; do not exceed 400 mg/day.
• Children under 6 months: Safety and efficacy have not been established.

Renal Dose:

• Renal Impairment: Dose reduction is necessary. If creatinine clearance (CrCl) is less than 20 ml/min, the maximum dose is 200 mg daily.

Important Considerations

Contraindications:

• Do not use AROFIX-100 Dry Syrup if you have a hypersensitivity to cephalosporins (a class of antibiotics that includes Cefixime).

Precautions:

• Use with caution if you have a history of allergy to penicillins.
• Use with caution during pregnancy and lactation. It is unknown whether the drug is excreted in breast milk.
• Exercise caution in patients with renal failure or gastrointestinal disease.

Interactions:

• Probenecid may increase Cefixime concentrations.
• Potentially Fatal: Cefixime may increase prothrombin time when used with anticoagulants.

Potential Side Effects

Side effects of Cefixime may include:

• More than 10%: Diarrhea (16%)
• Frequency Not Defined: Abdominal pain, candidiasis, dizziness, dyspepsia, elevated transaminases, eosinophilia, erythema multiforme, fever, flatulence, headache, increased blood urea nitrogen (BUN), increased creatinine, leukopenia, nausea, prolonged prothrombin time (PT), pruritus, pseudomembranous colitis, rash, serum sickness-like reaction, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis, vomiting.
• Potentially Fatal: Pseudomembranous colitis.