AROFIX-100

Description

AROFIX-100 DRY SYRUP: Cefixime 100mg/5ml

AROFIX-100 DRY SYRUP is an antibiotic containing Cefixime 100mg/5ml, manufactured by Arrow Pharmaceuticals Pvt Ltd. It’s available in Nepal for 180.00 NPR.

Other Available Forms:

• 50mg/5ml – Dry Syrup
• 100mg – Tablet
• 200mg – Tablet
• 400mg – Tablet

Uses (Indications)

AROFIX-100 DRY SYRUP is used to treat various susceptible bacterial infections, including:

• Pneumonia
• Pharyngitis
• Typhoid fever
• Sinusitis
• Otitis media
• Tonsillitis
• Soft tissue infections
• Respiratory tract infections (e.g., Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis)
• Gonococcal urethritis

How to Use (Administration & Dosage)

AROFIX-100 DRY SYRUP can be taken with or without food. Taking it with food or milk may help reduce stomach discomfort.

Adult Dose:

• Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg daily as a single dose or in two divided doses.
• Gonorrhea: 400 mg as a single dose.
• Typhoid Fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, which may be extended up to 14 days depending on infection severity.

Child Dose:

• Children weighing less than 50 kg: 8 mg/kg/day, given every 12-24 hours. For serious infections requiring convalescent oral therapy, up to 20 mg/kg/day.
• Powder for Suspension & DS Powder for Suspension:
  • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
  • 6 months – 1 year: 75 mg daily.
  • 1-4 years: 100 mg daily.
  • 5-10 years: 200 mg daily.
• Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days. Do not exceed 400 mg/day.
• Children under 6 months: Safety and efficacy have not been established.

Renal Impairment:

• Dose reduction is necessary.
• For a Creatinine Clearance (CrCl) less than 20 ml/min, the maximum dose is 200 mg daily.

Important Considerations

• Do Not Use If (Contraindications): Do not use AROFIX-100 DRY SYRUP if you have a known hypersensitivity to cephalosporin antibiotics.
• Precautions:
  • Inform your doctor if you have a history of allergy to penicillins.
  • Use with caution if you are pregnant or lactating.
  • Use with caution in patients with renal failure or Gastrointestinal (GI) disease.
  • Lactation: It’s unknown whether Cefixime is excreted in breast milk; use with caution.
• Interactions:
  • Probenecid: May increase Cefixime concentrations.
  • Anticoagulants: May potentially and fatally increase prothrombin time when used concurrently.

Possible Side Effects (Adverse Effects)

Very Common (>10%):

• Diarrhea (16%)

Frequency Not Defined (may occur):

• Abdominal pain, Candidiasis, Dizziness, Dyspepsia, Elevated transaminases, Eosinophilia, Erythema multiforme, Fever, Flatulence, Headache, Increased BUN (blood urea nitrogen), Increased creatinine, Leukopenia, Nausea, Prolonged prothrombin time (PT), Pruritus, Pseudomembranous colitis, Rash, Serum sickness-like reaction, Stevens-Johnson syndrome, Thrombocytopenia, Urticaria, Vaginitis, Vomiting.

Potentially Fatal:

• Pseudomembranous colitis

How It Works (Mechanism of Action)

Cefixime works by binding to specific penicillin-binding proteins (PBPs) in bacteria. This action inhibits the final step of peptidoglycan synthesis, which is crucial for bacterial cell wall formation. By disrupting cell wall assembly, Cefixime causes bacterial cell death.

Disclaimer: The information provided about AROFIX-00 DRY SYRUP is for general knowledge and informational purposes only. It is not intended for diagnosis, medical advice, or treatment, and should not be considered a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.