Adap

Description

Adap Gel (Adapalene 0.1% Topical)

Adap Gel is a topical medication used to treat certain skin conditions.

Uses

Adap Gel is indicated for the treatment of:

• Acne vulgaris (commonly known as acne, including pimples, blackheads, and whiteheads)
• Keratosis pilaris (a common, harmless skin condition characterized by dry, rough patches and small, bumpy spots)

Dosage and Administration

Adults:

• Topical Application: Apply a 0.1% solution, cream, or gel once daily, typically at night, after cleansing the skin.

Administration Instructions:

• This product is for topical use only.
• Apply a small, pea-sized amount sparingly to the entire affected facial area after cleansing with a non-medicated cleanser.

Important Considerations

Contraindications

Do not use Adap Gel if you have a known hypersensitivity (allergic reaction) to adapalene or any of its ingredients.

Precautions

Use Adap Gel with caution in the following situations:

• Sunburn: Avoid applying to sunburned skin.
• Eczema: Use with caution if you have eczema.
• Pregnancy and Lactation:
  • Pregnancy: Use with caution.
  • Lactation: It is not known whether adapalene is excreted in breast milk; therefore, use with caution during breastfeeding.
• Sun Exposure: Avoid excessive exposure to natural sunlight or artificial UV radiation (e.g., tanning beds). Always use sunscreen and protective clothing when exposed to the sun.
• Application Sites:
  • Keep the gel away from the eyes, lips, nostrils, and other mucous membranes.
  • Do not apply to cuts, abrasions, broken skin, or areas of scaly, flaky, or sunburned skin.
• Concomitant Products: Use with caution if you are also using other topical preparations that contain sulfur, resorcinol, or salicylic acid, as this may increase skin irritation.

Drug Interactions

Increased skin irritation may occur if Adap Gel is used alongside:

• Medicated or abrasive soaps.
• Products with a strong drying effect.
• Products containing alcohol or astringents.

Adverse Effects (Side Effects)

The most commonly reported side effects of Adapalene 0.1% Topical are:

Very Common (>10% of users):

• Dryness (reported in 1-45% of users)
• Scaling (reported in 1-44% of users)
• Burning/stinging sensation (reported in 4-29% of users)
• Erythema (redness) (reported in 0.5-26% of users)

Common (1-10% of users):

• Skin discomfort (6%)
• Pruritus (itching) (2%)
• Desquamation (peeling of skin) (2%)
• Sunburn (1%)

Uncommon (<1% of users):

• Acne flare-up
• Conjunctivitis (inflammation of the conjunctiva, “pink eye”)
• Contact dermatitis (skin inflammation due to contact with an irritant or allergen)
• Eczema
• Erythema (beyond the common range)
• Eyelid edema (swelling of the eyelids)
• Rash
• Skin discoloration

Mechanism of Action

Adapalene works by binding to specific retinoic acid nuclear receptors. This action helps to normalize the differentiation of follicular epithelial cells (cells lining the hair follicles), which in turn reduces the formation of microcomedones – the initial lesions that lead to acne.

Additional Information

• Adap 0.1% Gel is manufactured by Curex Pharmaceuticals Pvt. Ltd.
• Its generic name is Adapalene 0.1% Topical.
• Adap Gel is available in Nepal.

Disclaimer: This information is provided for general knowledge and is not intended for diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.