Acno T

Description

Acno T Cream (Tretinoin Topical) – Product Information

Indications: Acno T Cream is used for the topical treatment of:

• Acne vulgaris
• Mottled hyperpigmentation
• Roughness and fine wrinkling of photodamaged skin

Dosage and Administration:

Adults:

• Acne Vulgaris: Apply a thin layer to the affected area once daily, usually at bedtime. The skin should be cleansed to remove excessive oiliness and thoroughly dried before application. Therapeutic response may be observed after 6-8 weeks of consistent use.
• Mottled Hyperpigmentation, Roughness, and Fine Wrinkling of Photodamaged Skin: Apply a pea-sized amount to the entire face once daily at night. Therapeutic response may be observed after 6 months of consistent use.

Children:

• Acne Vulgaris:
  • Under 12 years of age: Safety and efficacy have not been established.
  • Over 12 years of age: Apply once daily, usually at bedtime, onto the affected area.

Renal Dose: (Information not provided in the original text)

Contraindications:

• Hypersensitivity to retinoids.
• Application to eczematous, sunburned, or abraded skin.
• Pregnancy.
• Lactation.

Precautions:

• Avoid concomitant use of other topical preparations, especially keratolytic agents.
• Minimize exposure to sunlight, UV light, and extreme weather conditions (e.g., cold).
• Avoid contact with eyes, mouth, angles of the nose, mucous membranes, or open wounds.
• If severe local erythema, edema, blistering, or crusting occurs, reduce frequency of application or discontinue use.
• Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing, and harsh scrubbing.
• Avoid topical preparations with high concentrations of alcohol, menthol, spices, or lime.

Pregnancy and Lactation:

• Acno T Cream is contraindicated during pregnancy and lactation.

Interactions:

• Enhanced Percutaneous Absorption: May enhance the percutaneous absorption of minoxidil.
• Increased Tretinoin Concentrations: Concurrent use with azole antifungals may increase tretinoin concentrations.
• Enhanced Peeling Action: May enhance the peeling action of sulfur, resorcinol, benzoyl peroxide, and salicylic acid.
• Increased Photosensitivity: Increased photosensitivity may occur when used with other photosensitizing medications such as thiazides, tetracyclines, fluoroquinolones, phenothiazines, and sulfonamides.
• Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.

Adverse Effects: Common side effects include:

• Initial exacerbation of symptoms (e.g., acne flare-up)
• Skin irritation, stinging on application
• Edema, blistering, crusting of the skin
• Erythema (redness), scaling
• Photosensitivity
• Temporary hypo/hyperpigmentation

Mechanism of Action: Tretinoin, a trans-retinoic acid form of Vitamin A, stimulates mitosis and turnover of follicular epithelial cells, reducing their cohesiveness. This action facilitates the extrusion of existing comedones and prevents the formation of new ones. It also exhibits a thinning effect on the stratum corneum. In acute promyelocytic leukemia, tretinoin induces cellular differentiation and decreases proliferation.

Note: Acno T 0.025% Cream is manufactured by Maruti Pharma Pvt. Ltd. and its generic name is Tretinoin Topical. Acno T is available in Nepal. This information is not intended for diagnosis, medical advice, or treatment, and should not be considered a substitute for professional medical judgment.