Acneris

Description

Dosage & How to Use

Adult Dose:

• Apply a thin film of the gel to the affected skin area once daily in the evening, before bed.

Child Dose:

• The safety and effectiveness of Acneris Gel in children under 12 years of age have not been established.

Application Instructions:

1. Cleanse your skin with a mild or soap-free cleanser.
2. Rinse your skin with water.
3. Apply a small amount of gel with clean fingers and gently rub it into the skin.
4. Use just enough to lightly cover the entire affected area.

Important Considerations

• Contraindications: Do not use Acneris Gel if you have a history of:
  • Hypersensitivity (allergy) to clindamycin, lincomycin, or adapalene.
  • Regional enteritis (Crohn’s disease).
  • Ulcerative colitis.
  • Antibiotic-associated colitis.
• Precautions:
  • Clindamycin Absorption: Even though it’s applied topically, clindamycin can be absorbed into the bloodstream. Cases of diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with both topical and systemic clindamycin. These gastrointestinal issues can sometimes appear several weeks after stopping oral or injected clindamycin.
  • Adapalene Use:
    • Avoid applying the gel to areas with cuts, scrapes, sunburned skin, or eczema.
    • Avoid contact with your eyes, mouth, angles of the nose, and other very sensitive body areas. If accidental contact occurs, wash immediately with warm water.
    • Sun Sensitivity: Limit exposure to strong sunlight and artificial UV light (like tanning beds). It’s recommended to use sunscreen products and wear protective clothing over treated areas.
• Lactation (Breastfeeding): It’s unknown if the active ingredients are excreted in breast milk. Use with caution if breastfeeding.
• Drug Interactions:
  • Clindamycin: Has neuromuscular blocking properties. Use with caution if you are also taking other neuromuscular blocking agents, as clindamycin may enhance their effects.
  • Adapalene: No known interactions with other topical medications. However, avoid using other retinoids or drugs with a similar mechanism of action concurrently with adapalene to prevent excessive skin irritation.
• Adverse Effects (Side Effects):
  • Local Effects (Common): Burning, itching, dryness, redness (erythema), and peeling at the application site.
  • Systemic Effects (Rare with Topical Clindamycin but reported): Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis). Abdominal pain, gastrointestinal disturbances, and gram-negative folliculitis have also been reported.
  • Adapalene-Specific Side Effects:
    • Common (up to 1 in 10 people): Dry skin, skin irritation, burning sensation, redness (erythema).
    • Uncommon (up to 1 in 100 people): Local skin reaction (contact dermatitis), skin discomfort, sunburn, itching (pruritus), peeling skin (exfoliation), and flare-up of acne.
• Mechanism of Action:
  • Clindamycin: Works by stopping bacterial growth. It binds to the 50S ribosomal subunit of susceptible bacteria, blocking protein synthesis necessary for their survival and reproduction. This helps control the bacterial component of acne.
  • Adapalene: A retinoid-like compound that binds to specific retinoic acid nuclear receptors. This action helps to normalize the growth and differentiation of follicular epithelial cells, which ultimately reduces the formation of microcomedones (the earliest type of acne lesion).