Acirab10

Description

Acirab10 Tablet: Uses, Dosing, and Important Information

Acirab10 Tablet, containing 10 mg of Rabeprazole, is a medication primarily used to reduce stomach acid. It is manufactured by Omnica Laboratories Pvt. Ltd. and is available in Nepal.

What is Acirab10 Tablet Used For?

Acirab10 Tablet is used to treat various conditions caused by excessive stomach acid, including:

• Peptic Ulcer Disease: To heal ulcers in the stomach and the upper part of the small intestine.
• H. pylori Infection: As part of a treatment regimen to eliminate this bacterium, which can cause ulcers.
• Gastro-Oesophageal Reflux Disease (GERD): To manage symptoms like heartburn and acid reflux, including erosive oesophagitis (inflammation of the oesophagus due to acid). It is used in both adults and children over 12 years old for this purpose.
• Zollinger-Ellison Syndrome: A rare condition that causes the stomach to produce too much acid.
• Acid-Related Dyspepsia: Indigestion caused by stomach acid.
• NSAID-Associated Ulceration: To prevent or treat ulcers caused by non-steroidal anti-inflammatory drugs.
• Ulcers Resistant to H2 Receptor Antagonists: For ulcers that haven’t responded to other types of acid-reducing medications.
• Gastrointestinal (GI) Bleeding from Stress: To help prevent or treat bleeding in the digestive tract that can be stress-related.
• Prophylaxis for Acid Aspiration Syndrome: To reduce the risk of stomach acid entering the lungs during the induction of anaesthesia.

How to Take Acirab10 Tablet (Dosing Information)

Important Note: Always take Acirab10 exactly as prescribed by your doctor. The doses listed below are general guidelines, and your doctor will determine the best dose for your specific condition.

• Administration: Acirab10 Tablet can be taken with or without meals. It is usually taken once in the morning.

Adult Dosing

• Gastro-oesophageal reflux disease (GERD):
  • Treatment: Typically 20 mg (two Acirab10 tablets) once daily for 4-8 weeks.
  • Maintenance: 10 mg (one Acirab10 tablet) or 20 mg (two Acirab10 tablets) once daily.
  • All doses are usually taken once in the morning.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg (six Acirab10 tablets) once daily, usually in the morning.
  • Your doctor may adjust the dose up to a maximum of 120 mg/day (twelve Acirab10 tablets). If the daily dose exceeds 100 mg, it may be given in two divided doses.
• Peptic Ulcer:
  • Duodenal ulcer: 20 mg (two Acirab10 tablets) once daily for 4-8 weeks.
  • Gastric ulcer: 20 mg (two Acirab10 tablets) once daily for 6-12 weeks.
• H. pylori Infection (1-week triple therapy):
  • Typically 20 mg (two Acirab10 tablets) twice daily, combined with specific antibiotics (e.g., clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily; OR clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily).
• Erosive Oesophagitis:
  • 20 mg (two Acirab10 tablets) once daily for 4-8 weeks. An additional 8 weeks may be considered if healing is incomplete.
  • Maintenance: 10 mg (one Acirab10 tablet) or 20 mg (two Acirab10 tablets) once daily.
  • All doses are usually taken once in the morning.
• Elderly Patients: No dosage adjustment is typically needed.
• Hepatic Impairment (Liver Problems): No specific dosage adjustment is typically needed, but use with caution in severe liver impairment.
• Renal Impairment (Kidney Problems): No dosage adjustment is typically needed.

Child Dosing (Oral)

• Gastro-oesophageal reflux disease (GERD):
  • Children >12 years: 20 mg (two Acirab10 tablets) once daily for up to 8 weeks.

Important Considerations and Warnings

Do Not Use If:

• You have a known hypersensitivity (allergy) to rabeprazole, other proton pump inhibitors (PPIs), or any other ingredients in Acirab10.
• You are concurrently using medications like rilpivirine or atazanavir.

Precautions:

• Your doctor should rule out gastric malignancy (stomach cancer) before you start this medication, as symptoms can be similar.
• Use with caution if you have severe hepatic impairment (severe liver problems).
• Pregnancy and Lactation: If you are pregnant or breastfeeding, discuss this with your doctor. It’s not fully known if rabeprazole passes into breast milk; therefore, caution is advised, and it’s generally not recommended.
• Monitoring: Your doctor may monitor your magnesium levels before starting Acirab10 and periodically during prolonged use. Long-term use of PPIs like rabeprazole can lead to low magnesium levels.
• Bone Fracture Risk: Prolonged and high-dose PPI therapy may be associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine.
• Clostridium difficile infection: PPIs may be associated with an increased risk of Clostridium difficile-associated diarrhoea. Report persistent diarrhoea to your doctor.

Possible Drug Interactions:

Acirab10 Tablet can interact with other medications, potentially affecting their effectiveness or increasing side effects. Be sure to inform your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal products.

• Decreased effectiveness of: Ketoconazole, itraconazole, clopidogrel, atazanavir, rilpivirine, sucralfate (take Acirab10 at least 30 minutes before sucralfate).
• Increased risk of side effects with: Digoxin (increased heart-related effects), diuretics (increased risk of low magnesium), warfarin (increased risk of bleeding due to altered INR/prothrombin time).
• Increased levels of: Methotrexate, saquinavir.
• Potentially Fatal: May significantly decrease plasma concentrations and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects:

Like all medications, Acirab10 can cause side effects, though not everyone experiences them.

Common (1–10% of patients):

• Headache
• Abdominal pain
• Diarrhoea
• Flatulence (gas)
• Constipation
• Pharyngitis (sore throat)
• General pain

Less Common (<1%, but potentially serious):

• Agitation
• Agranulocytosis (severe reduction in white blood cells)
• Anemia
• Angioedema (severe swelling under the skin)
• Chest pain
• Delirium
• Erythema (skin redness)
• Hypokalemia (low potassium)
• Hypomagnesemia (low magnesium levels)
• Hyponatremia (low sodium)
• Jaundice (yellowing of skin/eyes)
• Leukocytosis (high white blood cell count)
• Leukopenia (low white blood cell count)
• Migraine
• Osteoporosis-related fracture (bone fracture due to weakened bones)
• Rhabdomyolysis (muscle breakdown)
• Stevens-Johnson syndrome (a severe skin reaction)
• Sudden death
• Toxic epidermal necrolysis (a very severe and potentially fatal skin reaction)
• Abnormal taste

How Acirab10 Tablet Works (Mechanism of Action)

Rabeprazole, the active ingredient in Acirab10 Tablet, is a proton pump inhibitor (PPI). It works by blocking the H+/K+ ATPase enzyme system, often called the “proton pump,” which is located in the parietal cells of your stomach lining. This enzyme is responsible for the final step of acid secretion in the stomach. By inhibiting this pump, rabeprazole effectively reduces both the normal (basal) and stimulated production of stomach acid.

Disclaimer: This information about Acirab10 Tablet is for general knowledge and should not be used for self-diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.