Acirab 20

Description

About Acirab 20 Tablet

Acirab 20 Tablet, manufactured by Omnica Laboratories Pvt. Ltd. and available in Nepal, contains the active ingredient Rabeprazole. This medication is a proton pump inhibitor (PPI). It works by suppressing gastric acid secretion through inhibiting the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cells.

What is Acirab 20 Tablet Used For?

Acirab 20 Tablet is prescribed for various conditions related to stomach acid production, including:

• Peptic ulcer disease
• H. pylori infection
• Gastro-oesophageal reflux disease (GERD), including in pediatric patients
• Zollinger-Ellison syndrome
• Oesophagitis (inflammation of the esophagus)
• Acid-related dyspepsia (indigestion)
• NSAID-associated ulceration (ulcers caused by pain relievers)
• Ulcers resistant to H2 receptor antagonists
• Gastrointestinal (GI) bleeding from stress
• Prophylaxis for acid aspiration syndrome during the induction of anesthesia

Dosage Information

The appropriate dosage of Acirab 20 Tablet varies depending on the condition being treated and the patient’s age and health. All oral doses should generally be taken once in the morning.

Adult Dosing (Oral)

• Gastro-oesophageal reflux disease (GERD):
  • Treatment: 20 mg once daily for 4-8 weeks.
  • Maintenance: 10 mg or 20 mg once daily.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg once in the morning.
  • Adjusted: Up to a maximum dose of 120 mg/day if needed. Daily doses greater than 100 mg should be given in 2 divided doses.
• Peptic Ulcer:
  • Duodenal ulcer: 20 mg once in the morning for 4-8 weeks.
  • Gastric ulcer: 20 mg once in the morning for 6-12 weeks.
• H. pylori Infection (1-week triple therapy):
  • 20 mg twice daily, combined with clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR
  • 20 mg twice daily, combined with clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis:
  • Treatment: 20 mg once daily for 4-8 weeks. May continue for another 8 weeks if healing is incomplete.
  • Maintenance: 10 mg or 20 mg once daily.
• Elderly Patients: No dosage adjustment is needed.
• Hepatic Impairment: No dosage adjustment is needed.

Child Dosing (Oral)

• Gastro-oesophageal reflux disease (GERD):
  • Children >12 years: 20 mg once in the morning for up to 8 weeks.

Renal Impairment

• No dosage adjustment is needed for patients with renal impairment.

Administration Guidelines

• Acirab 20 Tablet can be administered with or without meals.

Important Considerations

Contraindications

Rabeprazole is contraindicated in patients with known hypersensitivity to rabeprazole, other PPIs, or any component of the formulation.

Precautions

• Gastric malignancy should be ruled out before starting treatment.
• Use with caution in patients with severe hepatic impairment.
• Use with caution during pregnancy and lactation.
• Monitoring Parameters: Your doctor will monitor magnesium (Mg) levels prior to initiation and periodically during prolonged use.

Lactation

• It is unknown whether rabeprazole is distributed into breast milk; therefore, use caution if breastfeeding.

Interactions with Other Medications

Acirab 20 Tablet can interact with various other medications, potentially altering their effects:

• May decrease serum concentration: Ketoconazole, itraconazole, and clopidogrel.
• Increased risk: Hypomagnesaemia with diuretics and digoxin.
• May increase: Prothrombin time and INR of warfarin, plasma concentration of saquinavir and methotrexate.
• Decreased serum levels: Sucralfate.
• Potentially Fatal: May significantly decrease the plasma concentrations and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects

Common side effects (1-10% of patients) include:

• Headache (2-10%)
• Abdominal pain (4%)
• Diarrhea (2-5%)
• Flatulence (3%)
• Pain (3%)
• Pharyngitis (3%)
• Constipation (2%)

Less common side effects (<1%) that have been reported include:

• Agitation
• Agranulocytosis
• Alopecia
• Anemia
• Angioedema
• Chest pain
• Delirium
• Erythema
• Hypokalemia
• Hypomagnesemia
• Hyponatremia
• Jaundice
• Leukocytosis
• Leukopenia
• Migraine
• Osteoporosis-related fracture
• Rhabdomyolysis
• Stevens-Johnson syndrome
• Sudden death
• Toxic epidermal necrolysis
• Abnormal taste

Important Note

This information about Acirab 20 Tablet is for general knowledge and is not intended as medical advice, diagnosis, or treatment. It should not replace the professional judgment of a healthcare provider. Always consult with your doctor or pharmacist for any health concerns or before making decisions about your medication.