Acidin

Description

Acidin Tablet (Ranitidine)

Acidin Tablet contains ranitidine, a type of medication known as an H2-receptor antagonist. It works by blocking histamine at certain receptors in the stomach, which significantly reduces the production of stomach acid.

What is Acidin Tablet used for?

Acidin Tablet is prescribed to treat and prevent conditions related to stomach acid, including:

• Peptic Ulcer Disease: This includes both benign gastric ulcers (stomach ulcers) and duodenal ulcers (ulcers in the upper part of the small intestine).
• H. pylori Infection: Used as part of a combination therapy to help eradicate Helicobacter pylori bacteria, which can cause ulcers.
• Gastro-oesophageal Reflux Disease (GERD): Also known as acid reflux, this condition involves symptoms like heartburn and acid regurgitation. It also treats erosive oesophagitis (damage to the esophagus from stomach acid).
• Dyspepsia: For indigestion or upset stomach. This includes chronic episodic dyspepsia and short-term symptomatic relief.
• Hypersecretory Conditions: Conditions where the stomach produces too much acid, such as Zollinger-Ellison Syndrome.
• Acid Aspiration during General Anesthesia: To prevent stomach acid from entering the lungs during surgery.
• Prophylaxis during NSAID Treatment: To prevent ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs).
• Stress Ulceration of Upper GI: To prevent ulcers that can develop during severe stress or illness.

How to take Acidin Tablet (Dosage Information)

Acidin Tablet can be taken with or without food.

Adult Dosing (Oral)

• Benign Gastric and Duodenal Ulceration:
  • Initial: 300 mg once daily at bedtime, or 150 mg twice daily, for 4-8 weeks. For duodenal ulcers, 300 mg twice daily for 4 weeks may improve healing.
  • Maintenance: 150 mg once daily at bedtime.
  • Maximum: 300 mg twice daily.
• Hypersecretory Conditions (e.g., Zollinger-Ellison Syndrome):
  • Initial: 150 mg twice or three times daily, and increased if needed.
  • Maximum: 6 grams daily.
• Gastro-oesophageal Reflux Disease (GERD):
  • 150 mg twice daily or 300 mg at bedtime for up to 8 weeks.
  • For severe cases, the dose may be increased to 150 mg four times daily for up to 12 weeks.
• Dyspepsia:
  • Chronic Episodic: 150 mg twice daily for up to 6 weeks.
  • Short-term Symptomatic Relief: 75 mg, repeated if necessary, up to 4 doses daily. Do not use continuously for more than 2 weeks at a time.
• Erosive Oesophagitis:
  • Treatment: 150 mg four times daily.
  • Maintenance: 150 mg twice daily.
• NSAID-associated Ulceration:
  • Treatment: 150 mg twice daily or 300 mg at bedtime for 8-12 weeks.
  • Prevention: 150 mg twice daily.

Child Dosing (Oral)

• Benign Gastric and Duodenal Ulceration (1 month to 16 years):
  • Treatment: 4-8 mg/kg daily, divided into two doses. Maximum: 300 mg/day. Treatment duration: 4-8 weeks.
  • Maintenance: 2-4 mg/kg once daily. Maximum: 150 mg/day.
• Gastro-oesophageal Reflux Disease (GERD) (1 month to 16 years):
  • 5-10 mg/kg daily, divided into two doses. Maximum: 300 mg/day.
• Erosive Oesophagitis (1 month to 16 years):
  • 5-10 mg/kg daily, divided into two doses. Maximum: 600 mg/day.

Special Populations

• Elderly: No dosage adjustment is typically needed.
• Hepatic Impairment (Liver Problems): No dosage adjustment is typically necessary.
• Renal Impairment (Kidney Problems):
  • Oral: If creatinine clearance (CrCl) is less than 50 mL/min, the dose is 150 mg once daily at bedtime. Adjust dose cautiously if needed.
  • Parenteral (IV/Injection): Individual doses may need to be reduced to 25 mg.

IV Administration (for Healthcare Professionals)

• Direct Injection: 50 mg diluted to at least 20 mL with a compatible IV infusion fluid and given over at least 5 minutes (4 mL/min).
• Intermittent Infusion: 50 mg added to at least 100 mL of a compatible IV solution and infused over 15-20 minutes.
• Continuous Infusion: 150 mg diluted in 250 mL of IV fluid and infused at 6.25 mg/hour for 24 hours.

Important Considerations

Do Not Take If:

• You have Porphyria (a group of rare genetic disorders that affect the nervous system or skin).

Precautions:

• Gastric Malignancy: Your doctor should rule out stomach cancer before you start treatment, as Acidin can sometimes mask the symptoms of cancer and delay diagnosis.
• Difficulty Swallowing: Use with caution if you have difficulty swallowing.
• Renal and Hepatic Impairment: Use with caution.
• Pregnancy and Lactation: If you are pregnant or breastfeeding, discuss with your doctor whether Acidin is safe for you. Ranitidine can pass into breast milk, so caution is advised, and you might need to discontinue the drug.

Potential Drug Interactions

Acidin Tablet can interact with other medications. It’s important to tell your doctor about all medicines you are taking, especially:

• Propantheline Bromide: May cause delayed absorption and increased peak serum concentration of Acidin.
• Minimal Inhibition of Hepatic Metabolism: Ranitidine minimally inhibits the liver’s processing of certain drugs, including coumarin anticoagulants (like warfarin), theophylline, diazepam, and propranolol.
• Altered Absorption of pH-dependent Drugs: May affect the absorption of drugs that require a specific stomach pH to work properly (e.g., ketoconazole, midazolam, glipizide).
• Antacids: May reduce the bioavailability (amount available to the body) of Acidin if taken together.
• Potentially Fatal: Anaphylaxis and other severe hypersensitivity reactions can occur.

Possible Side Effects

Like all medications, Acidin Tablet can cause side effects, though not everyone experiences them.

Common Side Effects (1-10% of users):

• Headache (3%)

Less Common Side Effects (Less than 1%):

• Abdominal pain
• Agitation
• Alopecia (hair loss)
• Confusion
• Constipation
• Diarrhea
• Dizziness
• Hypersensitivity reaction (allergic reaction)
• Nausea
• Vomiting

Rare Side Effects (Frequency Not Defined, but very uncommon):

• Anemia
• Necrotizing enterocolitis in fetus or newborn
• Pancreatitis (inflammation of the pancreas)
• Thrombocytopenia (low platelet count)
• Pancytopenia (low count of all blood cells)
• Agranulocytosis (severe drop in white blood cells)
• Acquired immune hemolytic anemia (a blood disorder)
• Arthralgia (joint pain)
• Myalgia (muscle pain)

Note: Acidin 150mg Tablet is manufactured by S.R. Drug Laboratories Pvt. Ltd. and is available in Nepal. This information is for general knowledge and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.