₨ NPR
Accuzon 1g
Accuzon 1g Injection, manufactured by Macleods Pharmaceuticals Pvt. Ltd., contains Ceftriaxone 1000mg as its active ingredient. It is available in Nepal, with other strengths including 250mg and 500mg injections. The retail price for Accuzon 1g is 90.00 NPR.
Accuzon 1g Injection is used to treat a variety of bacterial infections, including:
- Respiratory Tract Infections: Pneumonia, Acute otitis media, and other respiratory tract infections.
- Severe Systemic Infections: Meningitis, Typhoid fever, Septicemia, and Pelvic inflammatory disease.
- Other Infections: Lyme disease, Otitis media, Skin and Skin-Structure Infections, Gonorrhea, Urinary tract infections, Bone and Joint Infections, and Chlamydia infection. It is also used for Surgical Prophylaxis.
₨90.00
Ask about productDescription
Accuzon is contraindicated in:
- Individuals with hypersensitivity to cephalosporins.
- Hyperbilirubinemic neonates.
- It should not be used with or within 48 hours of calcium or calcium-containing solutions or products due to the risk of calcium-ceftriaxone precipitate formation.
Precautions
Exercise caution if you have:
- A history of penicillin allergy.
- Severe renal impairment.
- Are pregnant or lactating.
- Experience superinfection.
Lactation: The drug enters breast milk in low concentrations; use with caution.
Interactions
- May increase the nephrotoxicity of aminoglycosides.
- May diminish the therapeutic effect of BCG, typhoid vaccine, and sodium picosulfate.
- May increase the anticoagulant effect of vitamin K antagonists (e.g., warfarin).
- May increase serum levels with probenecid.
- Potentially Fatal: Administration with calcium-containing IV solutions may lead to precipitation of crystalline material in the lungs and kidneys.
Adverse Effects
- Common (greater than 10%): Induration after IM injection (5-17%).
- Less Common (1-10%): Eosinophilia (6%), Thrombocytosis (5%), Diarrhea (3%), Elevated hepatic transaminases (3%), Leukopenia (2%), Rash (2%), Increased blood urea nitrogen (BUN) (1%), Induration at IV site (1%), Pain (1%).
- Rare (less than 1%): Agranulocytosis, Anaphylaxis, Anemia, Basophilia, Bronchospasm, Candidiasis, Chills, Diaphoresis, Dizziness, Dysgeusia, Flushing, Gallstones, Glycosuria, Headache, Hematuria, Hemolytic anemia, Increased alkaline phosphatase or bilirubin, Increased creatinine, Jaundice, Leukocytosis, Lymphocytosis, Lymphopenia, Monocytosis, Nausea, Neutropenia, Phlebitis, Prolonged or decreased prothrombin time (PT), Pruritus, Renal stones, Serum sickness, Thrombocytopenia, Urinary casts, Vaginitis, Vomiting.
Mechanism of Action
Ceftriaxone works by binding to one or more penicillin-binding proteins (PBPs) in the bacterial cell wall. This action inhibits the final transpeptidation step of peptidoglycan synthesis, thereby disrupting bacterial cell wall assembly and leading to bacterial cell death.
Additional information
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