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SITA M 500
SITA M 500 is an oral antidiabetic medication containing a fixed-dose combination of Sitagliptin 50 mg and Metformin Hydrochloride 500 mg. It is used to improve glycemic control in adult patients with type 2 diabetes mellitus when lifestyle modifications and monotherapy with either component are not sufficient.
₨270.00
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SITA M 500 is an oral antidiabetic medication containing a fixed-dose combination of Sitagliptin 50 mg and Metformin Hydrochloride 500 mg. It is used to improve glycemic control in adult patients with type 2 diabetes mellitus when lifestyle modifications and monotherapy with either component are not sufficient.
Composition
- Sitagliptin Phosphate equivalent to Sitagliptin 50 mg
- Metformin Hydrochloride 500 mg
- Dosage Form: Film-coated bilayer tablet
- Route of Administration: Oral
Mechanism of Action
- Sitagliptin is a DPP-4 (dipeptidyl peptidase-4) inhibitor that enhances the body’s incretin system, promoting insulin secretion and reducing glucagon release after meals.
- Metformin works by reducing hepatic glucose production, enhancing insulin sensitivity, and decreasing intestinal absorption of glucose.
This dual-action formula helps regulate both fasting and postprandial blood glucose levels.
Indications
SITA M 500 is indicated for the treatment of:
- Type 2 diabetes mellitus in adults
- Patients inadequately controlled on Metformin or Sitagliptin monotherapy
- Those previously treated with Sitagliptin and Metformin as separate agents
Dosage and Administration
- Usual Dose: One tablet twice daily, or as directed by the physician
- Administration: Should be taken with meals to reduce gastrointestinal side effects
- Adjustment: Dosage may vary based on glycemic control and renal function
Storage
- Store below 30°C in a dry and cool place
- Protect from direct light and moisture
- Keep out of reach of children
Precautions
- Not recommended for patients with type 1 diabetes or diabetic ketoacidosis
- Monitor kidney function regularly due to risk of lactic acidosis with Metformin
- Caution in patients with hepatic impairment or dehydration
- Avoid use during pregnancy and breastfeeding unless advised by a healthcare provider
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