10% DEXTROSE 500/540ML GLASS BTL.

Description

10% Dextrose in a 500/540ml glass bottle refers to an intravenous (IV) solution containing 10 grams of dextrose (glucose) per 100 milliliters of solution, typically packaged in a 500ml or 540ml glass bottle for medical use.

Here’s a breakdown of its key aspects:

Uses:

• Fluid Replacement: It’s primarily used for short-term fluid replacement to treat hypovolemia (low blood volume) resulting from dehydration, injury, or burns.
• Calorie and Water Source: Provides calories (approximately 340 kcal/L) and water for hydration, especially when a patient cannot consume enough liquids orally, or after surgery or trauma.
• Hypoglycemia Treatment: Used to increase blood glucose levels in patients with hypoglycemia (low blood sugar), including newborns and infants.
• Parenteral Nutrition: High concentrations of dextrose are used as a carbohydrate source in parenteral nutrition regimens.
• Other uses: Can be used to decrease excessive pressure of spinal brain fluid and to treat hyperkalemia (high potassium levels in blood).

Composition:

• Each 100 mL typically contains 10 g of Dextrose Anhydrous I.P. and Water for Injection I.P. q.s.
• It is a hypertonic solution.

Administration:

• It is administered intravenously by a doctor or nurse. It should not be self-administered.
• It should be infused slowly.
• Avoid administering simultaneously with blood through the same IV set due to the risk of pseudoagglutination or hemolysis.

Side Effects: Common side effects include:

• Injection site reactions (pain, swelling, redness)
• Increased blood volume (hypervolemia)
• Electrolyte imbalance (e.g., hypokalemia – low potassium)
• Hyperglycemia (high blood sugar)
• Hemodilution (dilution of blood)

More serious, but less common, side effects can include:

• Allergic reactions (hives, difficulty breathing, swelling of face/lips/tongue/throat)
• Confusion
• Light-headedness
• Fever
• Swelling in hands or feet
• Sweating, pale skin, severe shortness of breath, chest pain
• Thrombosis (blood clots) if infused through peripheral veins with hypertonic solutions.

Precautions and Warnings:

• Diabetes: Use with caution in diabetic or pre-diabetic patients, and blood sugar levels should be monitored regularly.
• Kidney or Liver Disease: Use with caution, and dose adjustment may be needed. It is generally unsafe for patients with severe kidney disease.
• Heart Disease: Caution is advised, especially in patients with heart failure, to avoid circulatory overload.
• Electrolyte Imbalance: Can cause electrolyte imbalances, particularly hypokalemia or hyponatremia. Electrolyte concentrations and acid-base balance should be monitored.
• Pregnancy and Breastfeeding: Consult a doctor. Generally used with caution, and in breastfeeding, it may be advised to hold breastfeeding until the treatment is complete and the drug is eliminated.
• Corn Allergy: Individuals with a corn allergy may have an allergic reaction to dextrose.
• Head Injury/Intracranial Hemorrhage: Should not be used in cases of intracranial or intraspinal hemorrhage.
• Infants: Use with caution in infants, especially those with very low birth weights, as it may increase the risk of intracranial bleeding.

Storage:

• Typically stored below 25°C.
• Must remain sterile until use.
• Care should be taken during handling and transport to prevent damage to the bottle, which could lead to contamination.

Manufacturers: Several pharmaceutical companies manufacture 10% Dextrose solutions in glass bottles. Some examples include:

• Otsuka Pharmaceuticals Pvt Ltd.
• Amanta Healthcare Ltd.
• Albert David
• Eurocrit Labs
• B. Braun
• Krishnakeshav Laboratories

Important Note: This information is for general knowledge and informational purposes only, and does not constitute medical advice. Always consult a qualified healthcare professional for any medical concerns or before making any decisions related to your health or treatment.